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(±)-ML 209 

Cat. No. M28194

All AbMole products are for research use only, cannot be used for human consumption.

(±)-ML 209  Structure

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Quality Control & Documentation
Biological Activity

(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells.

Chemical Information
Molecular Weight 441.52
Formula C25H31NO6
CAS Number 1334526-14-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Dingfan Hu, et al. Int J Environ Res Public Health. Aerobic Degradation Characteristics and Mechanism of Decabromodiphenyl Ether (BDE-209) Using Complex Bacteria Communities

[2] Sunni Chen, et al. Toxicology. The combined impact of decabromodiphenyl ether and high fat exposure on non-alcoholic fatty liver disease in vivo and in vitro

[3] Xiangyang Li, et al. Environ Int. BDE-209 and DBDPE induce male reproductive toxicity through telomere-related cell senescence and apoptosis in SD rat

[4] Karin English, et al. J Hazard Mater. BDE-209 in the Australian Environment: Desktop review

[5] Lucio G Costa, et al. Neurotoxicology. Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant?

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  Catalog
Abmole Inhibitor Catalog




Keywords: (±)-ML 209  supplier, ROR, inhibitors, activators

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