| Cat.No. | Name | Information |
|---|---|---|
| M7321 | SR 1001 | SR 1001 is a RORα/γ inverse agonist with Ki values of 172 and 111 nM, respectively. |
| M25448 | Dehydrolithocholic acid | Dehydrolithocholic acid is a bile acid metabolite, which inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM). |
| M21105 | BI 730357 | BI 730357 is an orally active RORγt inhibitor for studies related to psoriasis. |
| M14531 | Cintirorgon | Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. |
| M11246 | SR0987 | SR0987, an analog of SR1078, is an agonist of RORγ T with an EC50 value of 800 nM. SR0987 up-regulated the expression of IL17 and inhibited the expression of PD-1. |
| M10929 | Cedirogant | Cedirogant (ABBV-157) is an orally active RORγt reverse agonist that can be used in the study of psoriasis. |
| M10170 | S18-000003 | S18-000003 is a potent, effective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of 29 nM. |
| M10106 | Neoruscogenin | Neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1). |
| M9265 | Vimirogant | Vimirogant (also known as AGN-242428 and VTP-43742) is a potent, selective and orally active RORγt inhibitor. |
| M9221 | GSK805 | GSK805 is a potent, orally bioavailable RORγγ Inhibitor, with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 assay. |
| M9220 | SR2211 | SR2211 is a synthetic RORγ-selective modulator, functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM. |
| M8943 | GSK2981278 | GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). |
| M5676 | SR1078 | SR1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ; increases transcription of RORα target genes; thought to increase p53 stability. |
| M5675 | SR3335 | SR3335 (ML-176) is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. |
| M56790 | ASN06917370 | ASN06917370 is a former orphan receptor GPR17 ligand for the study of neurodegenerative diseases. |
| M54670 | JTE-151 | JTE-151 is a RORγ inhibitor that suppresses overactive immune responses by inhibiting RORγ associated with Th17 cell activation.JTE-151 can be used in studies related to autoimmune diseases. |
| M54594 | SAR-441169 | SAR-441169 is a RORγt inverse agonist that can be used in studies related to psoriasis. |
| M54593 | GRC-39815 | GRC-39815 is a RORγt inverse agonist that can be used in studies related to chronic obstructive pulmonary disease. |
| M42605 | RORγ antagonist 1 | RORγ antagonist 1, a potent betulinic acid derivative, is an antagonist of RORγ (KD=0.18 μM). |
| M42604 | RORγt inverse agonist 31 | RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC50 of 0.428 μM. |
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