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ROR Retinoic Acid-related Orphan Receptor

Cat.No.  Name Information
M7321 SR 1001 SR 1001 is a RORα/γ inverse agonist with Ki values of 172 and 111 nM, respectively.
M25448 Dehydrolithocholic acid Dehydrolithocholic acid is a bile acid metabolite, which inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM).
M21105 BI 730357 BI 730357 is an orally active RORγt inhibitor for studies related to psoriasis.
M14531 Cintirorgon Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist.
M11246 SR0987 SR0987, an analog of SR1078, is an agonist of RORγ T with an EC50 value of 800 nM. SR0987 up-regulated the expression of IL17 and inhibited the expression of PD-1.
M10929 Cedirogant Cedirogant (ABBV-157) is an orally active RORγt reverse agonist that can be used in the study of psoriasis.
M10170 S18-000003 S18-000003 is a potent, effective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of 29 nM.
M10106 Neoruscogenin Neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).
M9265 Vimirogant Vimirogant (also known as AGN-242428 and VTP-43742) is a potent, selective and orally active RORγt inhibitor.
M9221 GSK805 GSK805 is a potent, orally bioavailable RORγγ Inhibitor, with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 assay.
M9220 SR2211 SR2211 is a synthetic RORγ-selective modulator, functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.
M8943 GSK2981278 GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
M5676 SR1078 SR1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ; increases transcription of RORα target genes; thought to increase p53 stability.
M5675 SR3335 SR3335 (ML-176) is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays.
M54670 JTE-151 JTE-151 is a RORγ inhibitor that suppresses overactive immune responses by inhibiting RORγ associated with Th17 cell activation.JTE-151 can be used in studies related to autoimmune diseases.
M54594 SAR-441169 SAR-441169 is a RORγt inverse agonist that can be used in studies related to psoriasis.
M54593 GRC-39815 GRC-39815 is a RORγt inverse agonist that can be used in studies related to chronic obstructive pulmonary disease.
M42605 RORγ antagonist 1 RORγ antagonist 1, a potent betulinic acid derivative, is an antagonist of RORγ (KD=0.18 μM).
M42604 RORγt inverse agonist 31 RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC50 of 0.428 μM.
M40962 PF-06763809 PF-06763809 is a nuclear receptor ROR-γ antagonist that may be used in studies related to psoriasis.




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