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SR2211 is a synthetic RORγ-selective modulator that potently inhibits production of IL-17 in cells. In vitro, treatment of EL4 with SR2211 represses the IL-17 gene expression. Similarly, the expression of IL-23 receptor (Il23r) is significantly inhibited by SR2211. Treatment of EL-4 cells with SR2211 results in significant inhibition of IL-17 intracellular staining as compared to vehicle treated cells.
| Molecular Weight | 527.48 |
| Formula | C26H24F7N3O |
| CAS Number | 1359164-11-6 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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