Free shipping on all orders over $ 500

S18-000003

Cat. No. M10170
S18-000003 Structure
Synonym:

S18000003

Size Price Availability Quantity
5mg USD 370  USD370 In stock
10mg USD 620  USD620 In stock
25mg USD 1120  USD1120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

S18-000003 is a potent, effective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of 29 nM. S18-000003 inhibits Th17 cells from naive CD4+T cells. S18-000003 inhibits IL-17 production in the skin of IL-23-treated mice in a dose-dependent manner.

Chemical Information
Molecular Weight 518.55
Formula C26H25F3N2O4S
CAS Number 2068119-11-7
Solubility (25°C) DMSO 100 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chihiro Imura, et al. J Dermatol Sci. A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations

[2] Yoshikazu Sasaki, et al. Bioorg Med Chem Lett. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003

Related ROR Products
Dehydrolithocholic acid

Dehydrolithocholic acid is a bile acid metabolite, which inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM).

Zilovertamab

Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling.

SHR168442

SHR168442 is a modulator of RORγ with an IC50 value of 0.035 μM. It can be used as a skin-restricted topical compound for the study of psoriasis.

Cintirorgon

Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist.

Neoruscogenin

Neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).

  Catalog
Abmole Inhibitor Catalog




Keywords: S18-000003, S18000003 supplier, ROR, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.