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S18-000003 is a potent, effective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of 29 nM. S18-000003 inhibits Th17 cells from naive CD4+T cells. S18-000003 inhibits IL-17 production in the skin of IL-23-treated mice in a dose-dependent manner.
| Molecular Weight | 518.55 |
| Formula | C26H25F3N2O4S |
| CAS Number | 2068119-11-7 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | -20°C, sealed |
| Related ROR Products |
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JTE-151 is a RORγ inhibitor that suppresses overactive immune responses by inhibiting RORγ associated with Th17 cell activation.JTE-151 can be used in studies related to autoimmune diseases. |
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| GRC-39815
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| RORγ antagonist 1
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