About 30 results found for searched term "S-23" (0.004 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1657 | Atazanavir Sulfate | HIV Protease |
| BMS-232632, Reyataz, CGP-73547 | ||
| Atazanavir sulfate (BMS-232632, Reyataz) is an azapeptide inhibitor of HIV-1 protease. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. | ||
| M1686 | Bortezomib (PS-341) | Proteasome |
| Velcade; PS-341; LDP 341; MG 341; NSC 681239 | ||
| Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. | ||
| M1703 | Deforolimus | mTOR |
| Ridaforolimus, AP23573, MK-8669 | ||
| Deforolimus (also known as AP23573 and MK-8669) is an investigational targeted and small-molecule mTOR inhibitor. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M1772 | PKI-587 | PI3K |
| Gedatolisib; PF-05212384 | ||
| PKI-587 (Gedatolisib; PF-05212384) is a highly potent dual PI3K/mTOR kinase inhibitor with the IC50 value of 0.4nM. | ||
| M1777 | SGX523 | c-Met |
| SGX-523 | ||
| SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. | ||
| M1786 | Ispinesib | Kinesin |
| SB-715992, CK0238273 | ||
| Ispinesib (SB 715992) is the first potent, highly specific small-molecule inhibitor of kinesin spindle protein (KSP) with an IC50 of 4.1 nM. | ||
| M2021 | AG 18 | EGFR/HER2 |
| RG-50810；Tyrphostin 23；tyrA23；Tyrphostin A23 | ||
| AG-18 (Tyrphostin A23, tyrA23) inhibits EGFR with an IC50 of 35 μM. TyrA23 is also an inhibitor of CME and inhibits transferrin receptor internalization. | ||
| M2115 | GSK2334470 | PDK1 |
| GSK2334470 is a highly specific and potent inhibitor of PDK1 with IC50 of 10 nM. | ||
| M2161 | Navarixin | CXCR |
| SCH 527123; MK-7123 | ||
| Navarixin (SCH 527123) is a novel, selective CXCR2 receptor antagonist with IC50 of 3 nM. Navarixin (SCH 527123) has Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly. | ||
| M2171 | GSK923295 | Kinesin |
| GSK923295 is an allosteric inhibitor of CENP-E with Ki value of 3.2 nM. | ||
| M2256 | Ivermectin (MK-933) | Autophagy |
| Stromectol; MK-933; CD-5024; K-237 | ||
| Ivermectin (MK-933) is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Importin α5 inhibitor ivermectin effectively abrogates STAT1-importin α5 interactions. | ||
| M2465 | BMS-833923 | Smo |
| XL139 | ||
| BMS-833923 is an orally bioavailable Smoothened antagonist. | ||
| M2501 | Cepharanthine | NF-κB |
| NSC-623442 | ||
| Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. | ||
| M2540 | Creatinine | Others |
| NSC13123 | ||
| Creatinine is a break-down product of creatine phosphate in muscle. | ||
| M2567 | VS-5584 | PI3K |
| SB2343 | ||
| VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively. | ||
| M2786 | JSH-23 | NF-κB |
| Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. | ||
| M2790 | K252a | PKC |
| SF 2370; Antibiotic K-252a; Antibiotic SF 2370 | ||
| K252a is an inhibitor of the BDNF receptor TrkB. K-252a inhibits protein kinase with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene. | ||
| M2889 | NSC23766 trihydrochloride | GTPase |
| NSC23766 3HCl salt | ||
| NSC23766 3HCl is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA. | ||
| M2892 | NSC697923 | E1/E2/E3 Enzyme |
| NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. | ||
| M3385 | Cimetidine | Histamine Receptor |
| SKF-92334 | ||
| Cimetidine, a histamine congener, competitively inhibits histamine binding to histamine H2 receptors. | ||
| M3499 | Ezetimibe | Autophagy |
| SCH 58235 | ||
| Ezetimibe (Zetia) is a beta-lactam analog that targets NPC1L1, thereby lowering blood cholesterol levels. In addition, Ezetimibe can prevent spinal cord injury by inhibiting apoptosis through activation of autophagy and modulation of the PI3K/AKT/mTOR signaling pathway, which can be used in studies related to spinal cord injury. | ||
| M3621 | Ionomycin | Calcium Channel |
| SQ23377 | ||
| Ionomycin is a calcium ionophor and an antibiotic produced by Streptomyces conglobatus. | ||
| M3622 | Vernakalant | Potassium Channel |
| RSD-1235 | ||
| Vernakalant (RSD-1235) is an investigational mixed ion channel blocker, which can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents. | ||
| M3641 | XL413 | CDK |
| BMS-863233 | ||
| XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM. | ||
| M3696 | Rostafuroxin | ATPase |
| PST 2238 | ||
| Rostafuroxin, a novel antihypertensive compound, acts as a selective inhibitor of srC-SH2 interaction with Na, K-ATPase activated by mutated adducin and Wabin in vivo. | ||
| M3715 | GSK2838232A | HIV Protease |
| GSK2838232 is a novel human immune virus (HIV) maturation inhibitor being developed for the treatment of chronic HIV infection. | ||
| M3815 | Pasireotide | Somatostatin Receptor |
| SOM230 | ||
| Pasireotide is a somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin analogs. | ||
| M3835 | Alirocumab | PCSK9 |
| REGN 727；SAR 236553 | ||
| Alirocumab is a humanized IgG1 PCSK9 monoclonal antibody that can be used in the study of hypercholesterolemia. | ||
| M3917 | PD 123319 | Angiotensin Receptor |
| (S)-(+)-PD 123319 | ||
| PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. | ||
| M3921 | Dioscin | Autophagy |
| CCRIS 4123, Collettiside III | ||
| Dioscin (CCRIS 4123, Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. | ||
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