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XL413 inhibits the cell proliferation. XL413 decreases cell viability and elicits the caspase 3/7 activity in Colo-205 cells. XL413 results in modified S phase progression that subsequently leads to apoptotic cell death. XL413, at the 3 mg/kg dose, causes 70% inhibition of phosphorylated MCM2, and causes significant tumor growth regression at the 100 mg/kg dose.
Cell Experiment | |
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Cell lines | Colo-205 cells |
Preparation method | Using BrdU incorporation assay to measure the cell proliferation , and by Cell Titer–Glo kits to assay viability . |
Concentrations | ~10 μM |
Incubation time | 24 hours |
Animal Experiment | |
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Animal models | Mice bearing Colo-205 xenografts |
Formulation | |
Dosages | ~100 mg/kg |
Administration | p.o. |
Molecular Weight | 326.18 |
Formula | C14H13Cl2N3O2 |
CAS Number | 1169562-71-3 |
Solubility (25°C) | DMSO 10 mM |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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