About 21 results found for searched term "Reverse T3" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M30323 | Reverse T3 | Thyroid Hormone Receptor |
| 3′,5′,3-Triiodothyronine | ||
| Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes. | ||
| M11352 | Coniferyl ferulate | Others |
| Coniferyl ferulate is a potent glutathione S-transferase (GST) inhibitor that reverses multidrug resistance and down-regulates p-glycoprotein. Coniferyl ferulate strongly inhibited human placental glutathione S-transferase with IC50 of 0.3 μM. | ||
| M2137 | Stavudine | Reverse Transcriptase |
| d4T | ||
| Stavudine (D4T) is a potent inhibitor of HIV-1 reverse transcriptase in vitro. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis. | ||
| M3381 | Nevirapine | Reverse Transcriptase |
| BI-RG 587; NSC 641530; NVP | ||
| Nevirapine (NSC 641530) is a potent, specific non-nucleoside reverse transcriptase inhibitor (NNRTIs) that non-competitively inhibits human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with a Ki of 220 nM. Nevirapine (NSC 641530) can be used in AIDS-related researchs. | ||
| M5605 | Efavirenz | Reverse Transcriptase |
| Sustiva, Stocrin, DMP-266 | ||
| Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture. | ||
| M9585 | MAC-545496 | Anti-infection |
| MAC-545496 is potent GraR inhibitor (glycopeptide-resistance-associated protein R), reverses β-lactam resistance in the community-acquired MRSA USA300 strain. | ||
| M10863 | NCGC00378430 | Others |
| NCGC00378430 is a potent inhibitor of the SIX1/EYA2 interaction. NCGC00378430 partially reverses SIX1 overexpression-mediated transcription and metabolic profiling, and reverses SIX1-induced TGF-β signaling and epithelial-interstitial transformation (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in mouse models. | ||
| M10891 | Taranabant | Others |
| MK-0364 | ||
| Taranabant is a potent and selective cannabinoid 1 (CB1) receptor reverse agonist that inhibits binding and the functional activity of multiple agonists, acting on human CB1R,Ki 0.13 nM. | ||
| M11279 | GNE-6468 | Others |
| Gne-6468 is a potent and selective RORγ (RORc) reverse agonist with an EC50 value of 2 nM. Gne-6468 inhibited IL-17 in PBMC with EC50 value of 30 nM. | ||
| M19373 | Corydine | Reverse Transcriptase |
| Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC50 of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/䲧瓰Ỵ瓱 㧀瓯羹瓗 | ||
| M20577 | Doravirine | Reverse Transcriptase |
| MK1439 | ||
| Doravirine (MK-1439) is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. | ||
| M20702 | Alovudine | Reverse Transcriptase |
| CL 184824, FddThd, FLT, MIV-310 | ||
| 3'-Fluoro-3'-deoxythymidine (Alovudine) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. | ||
| M27630 | Azvudine | Reverse Transcriptase |
| RO-0622; FNC | ||
| Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains. | ||
| M28045 | GB83 | PAR |
| GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons. | ||
| M28185 | Azvudine hydrochloride | Reverse Transcriptase |
| RO-0622 hydrochloride; FNC hydrochloride | ||
| Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains. | ||
| M29059 | SJ-3366 | HIV Protease |
| IQP-0410 | ||
| SJ-3366 (IQP-0410) is a potent inhibitor of HIV nonnucleoside reverse transcriptase. SJ-3366 (IQP-0410) inhibits HIV at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism. | ||
| M29510 | SRI-37330 hydrochloride | Others |
| SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research. | ||
| M29668 | YS-370 | P-glycoprotein |
| YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity. | ||
| M30402 | Censavudine | HIV Protease |
| OBP-601; BMS-986001; TPN-101 | ||
| Censavudine (OBP-601; BMS-986001), a nucleoside analog, is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent HIV inhibitor with EC50 ranges from 30 nM to 81 nM and 450 nM to 890 nM for HIV-2 and HIV-1, respectively. | ||
| M30742 | Islatravir | HIV Protease |
| MK-8591 | ||
| Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. | ||
| M38655 | N-Acetyltyramine | Antibiotic |
| N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells. | ||
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