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Corydine

Cat. No. M19373
Corydine Structure
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Biological Activity

Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC50 of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/䲧瓰Ỵ瓱㧀瓯羹瓗

Chemical Information
Molecular Weight 341.4
Formula C20H23NO4
CAS Number 476-69-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nurfida Ablajan, et al. Nat Prod Res. Chemical components of Aconitum barbatum var. puberulum and their cytotoxic and antibacterial activities

[2] Teresa Kaserer, et al. Sci Rep. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists

[3] A Shafiee, et al. Planta Med. Corydine and norcorydine from the roots of Chelidonium majus

[4] Y Kondo, et al. J Pharmacobiodyn. Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine

[5] M Gerecke, et al. Helv Chim Acta. Selective ther cleavage in the aporphine series. Conversion of (S)-bulbocapnine into (S)-corytuberine and (S)-corydine methyl ether

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Keywords: Corydine supplier, Reverse Transcriptase, inhibitors, activators

 
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