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Islatravir

Cat. No. M30742

All AbMole products are for research use only, cannot be used for human consumption.

Islatravir Structure
Synonym:

MK-8591

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Quality Control & Documentation
Biological Activity

Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.

Chemical Information
Molecular Weight 293.25
Formula C12H12FN5O3
CAS Number 865363-93-5
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Water 3.57 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Abdallah Derbalah, et al. Curr Opin HIV AIDS. Role of islatravir in HIV treatment and prevention: an update

[2] Luis Menéndez-Arias, et al. Trends Pharmacol Sci. Update and latest advances in antiretroviral therapy

[3] Maria Chiara Masone. Nat Rev Urol. Islatravir implant as HIV-1 pre-exposure treatment

[4] Mark A Huffman, et al. Science. Design of an in vitro biocatalytic cascade for the manufacture of islatravir

[5] Martin Markowitz, et al. Curr Opin HIV AIDS. Islatravir for the treatment and prevention of infection with the human immunodeficiency virus type 1

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Keywords: Islatravir, MK-8591 supplier, HIV Protease, inhibitors, activators

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