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Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.
Molecular Weight | 293.25 |
Formula | C12H12FN5O3 |
CAS Number | 865363-93-5 |
Form | Solid |
Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) Water 3.57 mg/mL (ultrasonic and warming and heat to 60°C) |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Maria Chiara Masone. Nat Rev Urol. Islatravir implant as HIV-1 pre-exposure treatment
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