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TIM-3-IN-2 is a Tim3 inhibitor (KD: 0.61 μM). TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines.
| Molecular Weight | 461.47 |
| Formula | C25H23N3O6 |
| CAS Number | 1113126-49-0 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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