Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
| Molecular Weight | 650.97 |
| Formula | C15H12I3NO4 |
| CAS Number | 5817-39-0 |
| Form | Solid |
| Solubility (25°C) | Water 3.57 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | Powder -20°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Hung-Yun Lin, et al. Endocr Res. Action of Reverse T3 on Cancer Cells
[3] Y Ochi, et al. Nihon Rinsho. [Reverse T3 (rT3)]
[5] S F Grebe, et al. Acta Med Austriaca. [Reverse T3 values]
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