Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M50376 | Parathyroid hormone (1-34) (rat) | Parathyroid hormone (1-34) (rat) is a parathyroid hormone. |
| M30323 | Reverse T3 | Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes. |
| M25600 | MB-07811 | MB-07811 (VK2809) is an orally active, thyroid hormone receptor (THR)-beta agonist that can be used in studies related to hyperlipidemia and nonalcoholic steatohepatitis (NASH). |
| M10540 | PCO371 | PCO371 is a novel, orally active small molecule full agonist of PTHR1. PCO371 does not affect the PTH type 2 receptor (PTHR2). |
| M6746 | Sobetirome | Sobetirome is a thyroxine mimetic and a high affinity agonist for the thyroid hormone receptors THR-β and THR-α (KD values 67 and 440 pM, respectively). The in vitro effects on TRα1 and TRβ1 receptors are 5 and 100 times stronger than those of the endogenous agonist T3, respectively. |
| M6079 | Liothyronine | Liothyronine (3,3',5-Triiodo-L-thyronine; T3) is a potent agonist of both thyroid hormone receptors TRα and Trβ with Kis of 2.3 nM for both. This product is soluble but easy to precipitate after freezing in DMSO. NaOH is recommended as a stock solution. |
| M5987 | Taltirelin acetate | Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM. |
| M5759 | L-Thyroxine sodium salt pentahydrate | L-thyroxine sodium salt pentahydrate (L-thyroxine sodium pentahydrate; Levothyroxine, both found to lower total and LDL cholesterol levels. L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic thyroid hormone used in the study of hypothyroidism. |
| M3184 | Resmetirom (MGL-3196) | Resmetirom (MGL-3196, VIA-3196, resmetirom) is a potentially first-in-class, liver-targeted, orally active, selective thyroid hormone receptor (THR)-β agonist with an EC50 value of 0.21 μM. Resmetirom avoids the activation of THR-α receptors that mediate thyroid hormone activity outside of the liver, including the heart and bone. Resmetirom avoids the activation of THR-α receptors that mediate extrahepatic (including cardiac and skeletal) thyroid hormone activity and can be used in studies of non-alcoholic steatohepatitis (NASH). |
| M3073 | Tiratricol | Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue. |
| M57253 | 3,5-Diiodothyropropionic acid | 3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M-1 for TRα1 and TRβ1, respectively. |
| M54586 | ZYT-1 | ZYT-1 is a thyroid receptor (THR-β) agonist. |
| M54585 | VK-0214 | VK-0214 is an orally active, selective small molecule agonist of the thyroid receptor (THR-β) for studies related to X-linked adrenoleukodystrophy (X-ALD) and hyperlipidemia. |
| M54583 | PF-00277343 | PF-00277343 is a selective thyroid receptor (THR-β) agonist. |
| M54266 | Parathyroid Hormone (1-34), bovine | Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. |
| M54209 | (D-Trp12, Tyr34)-pTH (7-34) amide (bovine) | (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. |
| M54043 | (Glu2)-TRH | (Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), is a negative modulator for the cholinergic effect of TRH in the mouse brain. |
| M50375 | DPC-AJ1951 | DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). |
| M50374 | [Phe2]-TRH | [Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin. |
| M50373 | Human PTH-(1-31) amide | Human PTH-(1-31) amide is a PTH analog. |
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