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Resmetirom (MGL-3196)

Cat. No. M3184
Resmetirom (MGL-3196) Structure

VIA-3196; MGL-3196

Size Price Availability Quantity
2mg USD 55  USD55 In stock
5mg USD 100  USD100 In stock
10mg USD 150  USD150 In stock
25mg USD 260  USD260 In stock
50mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Resmetirom (MGL-3196) is a liver-targeted selective agonist for the thyroid hormone receptor-β (THR-β) designed to increase cholesterol uptake into the liver and increase its metabolism. Resmetirom (MGL-3196) was well-tolerated at all doses with no dose-related adverse events or liver enzyme, ECG or vital-sign changes. Resmetirom (MGL-3196) showed a beneficial effect on lipid parameters.

Customer Product Validations & Biological Datas
Source Atherosclerosis (2013). Figure 1. MGL-3196
Method i.v.
Cell Lines mice
Concentrations 0.25, 1, 2.5, 5, 10, 20, 50, 100 and 200 mg
Incubation Time 24-h
Results MGL-3196 appeared safe and was well-tolerated at all doses and no maximal tolerated dose was reached. Adverse events were mild, not dose-related or considered related to study drug. There were no effects on 24-h Holter heart rate, ECG intervals including QTcF (Fridericia’s correction), or blood pressure.
Chemical Information
Molecular Weight 435.22
Formula C17H12Cl2N6O4
CAS Number 920509-32-6
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Stephen A Harrison, et al. Effects of Resmetirom on Noninvasive Endpoints in a 36-Week Phase 2 Active Treatment Extension Study in Patients With NASH

[2] Bo Shen, et al. Efficacy and safety of drugs for nonalcoholic steatohepatitis

[3] Erenie Guirguis, et al. Emerging therapies for the treatment of nonalcoholic steatohepatitis: A systematic review

[4] Suzanna L Attia, et al. Evolving Role for Pharmacotherapy in NAFLD/NASH

[5] Stephen A Harrison, et al. Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

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Keywords: Resmetirom (MGL-3196), VIA-3196; MGL-3196 supplier, Thyroid Hormone Receptor, inhibitors, activators

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