L-thyroxine sodium salt pentahydrate (L-thyroxine sodium pentahydrate; Levothyroxine, both found to lower total and LDL cholesterol levels. L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic thyroid hormone used in the study of hypothyroidism.
| Molecular Weight | 888.93 |
| Formula | C15H20I4NNaO9 |
| CAS Number | 6106-07-6 |
| Form | Solid |
| Solubility (25°C) | 28 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Thyroid Hormone Receptor Products |
|---|
| Eneboparatide
Eneboparatide is a straight-chain peptide consisting of 36 amino acids and a long-acting parathyroid hormone (PTH1) receptor agonist that restores balanced bone turnover and maintains bone integrity while maintaining calcium homeostasis and normalizing urinary calcium. It can be used in studies related to parathyroid dysfunction. |
| ABX-002
ABX-002 is a selective, CNS-permeable thyroid hormone receptor beta (THR-β) agonist for use in studies related to major depressive disorder (MDD). |
| THRβ receptor agonist-1
THRβ receptor agonist-1 is a THRβ receptor agonist. |
| Thyroid hormone receptor beta agonist-1
Thyroid hormone receptor beta agonist-1 is a thyroid beta-agonist. |
| THR-β modulator-1
THR-β modulator-1 is a potent thyroid hormone receptor β modulator. |
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