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L-Thyroxine sodium salt pentahydrate

Cat. No. M5759
L-Thyroxine sodium salt pentahydrate Structure

Sodium levothyroxine pentahydrate

Size Price Availability Quantity
500mg USD 60  USD60 In stock
1g USD 78  USD78 In stock
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Quality Control & Documentation
Biological Activity

L-thyroxine sodium salt pentahydrate (L-thyroxine sodium pentahydrate; Levothyroxine, both found to lower total and LDL cholesterol levels. L-Thyroxine sodium salt pentahydrate (Levothyroxine;  T4) is a synthetic thyroid hormone used in the study of hypothyroidism.

Chemical Information
Molecular Weight 888.93
Formula C15H20I4NNaO9
CAS Number 6106-07-6
Form Solid
Solubility (25°C) 28 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Karp WB, et al. Pediatr Res. The effect of hydrocortisone, thyroxine, and phenobarbital on diamine oxidase activity in newborn rat intestine.

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Keywords: L-Thyroxine sodium salt pentahydrate, Sodium levothyroxine pentahydrate supplier, Thyroid Hormone Receptor, inhibitors, activators

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