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Cat. No. M3073
Tiratricol Structure

3,3',5-Triiodothyroacetic acid

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100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.

Chemical Information
Molecular Weight 621.93
Formula C14H9I3O4
CAS Number 51-24-1
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Riccardo Zucchi, et al. Novel thyroid hormones

[2] Janna Cohen-Lehman, et al. Tiratricol-induced periodic paralysis: a review of nutraceuticals affecting thyroid function

[3] Laura Cascales, et al. Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell

[4] S I Sherman, et al. Augmented hepatic and skeletal thyromimetic effects of tiratricol in comparison with levothyroxine

[5] S I Sherman, et al. Organ-specific effects of tiratricol: a thyroid hormone analog with hepatic, not pituitary, superagonist effects

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Keywords: Tiratricol, 3,3',5-Triiodothyroacetic acid supplier, Thyroid Hormone Receptor, inhibitors, activators

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