About 33 results found for searched term "Prostaglandin E2" (0.093 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5929 | Prostaglandin E2 | Prostaglandin Receptor |
| Dinoprostone; PGE2 | ||
| Prostaglandin E2 is a vasodilator isolated from prostate gland secretion, working by binding and activating the prostaglandin E2 receptor. | ||
| M43605 | 15-keto-Prostaglandin E2 | Prostaglandin Receptor |
| 15-keto-Prostaglandin E2 is an endogenous metabolite. | ||
| M55668 | Recombinant Human PTGDS Protein (HEK293, C-6His) | Cytokines and Growth Factors |
| PGD2 Synthase; PGDS2; Prostaglandin-D2 Synthase; Prostaglandin-H2 D-Isomerase | ||
| Prostaglandin-D2 Synthase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions, such as sedation, REM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. | ||
| M56311 | 11-Deoxy Prostaglandin E2 | Prostaglandin Receptor |
| 11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC50 of 0.66 nM. | ||
| M2458 | Bismuth Subsalicylate | Others |
| Bismuth oxysalicylate; Bismuth(III) salicylate basic | ||
| Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2. | ||
| M2471 | Bromfenac Sodium | COX |
| Bromfenac is a nonsteroidal anti-inflammatory compound (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. | ||
| M3809 | Isofraxidin | COX |
| IFD | ||
| Isofraxidin is an anti-bacterial, anti-oxidant, and anti-inflammatory agent, it acts by reducing the levels of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and prostaglandin E2 (PGE2), inhibiting cyclooxygenase-2 (COX-2) protein expression. | ||
| M4655 | Byakangelicol | COX |
| Byakangelicol is white triol separated from Angelica dahurica, Interleukin-1 β (IL-1β) -induced release of prostaglandin E2 (PGE2) in A549 cells was inhibited by inhibiting the expression and activity of coX-2. Byakangelicol can be used to study airway inflammation. | ||
| M4930 | SW033291 | Dehydrogenase |
| SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues. | ||
| M6714 | Epoprostenol sodium | Prostaglandin Receptor |
| Epoprostenol is an endogenous steroid and a selective agonist of the prostaglandin I2 receptor (PI2R) that inhibits platelet aggregation and induces vasodilation. It can be used in studies related to pulmonary hypertension. | ||
| M7051 | NS-398 | COX |
| NS398 | ||
| NS-398 is a cyclooxygenase-2 (COX-2) inhibitor, selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM. NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects. | ||
| M8120 | PF-04217329 | Others |
| PF-04217329 is a selective and potent prostaglandin EP2 receptor agonist. | ||
| M8780 | ONO-AE3-208 | Prostaglandin Receptor |
| AE 3-208 | ||
| ONO-AE3-208 is an orally active prostaglandin E2 receptor 4 (EP4)-selective antagonist (Ki in nM = 1. | ||
| M8900 | TG6-10-1 | 5-HT Receptor |
| TP-6101 | ||
| TG6-10-1 is a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2. | ||
| M9232 | PF-04418948 | Prostaglandin Receptor |
| PF-04418948 is a novel, potent and selective prostaglandin EP2 receptor antagonist with IC50 of 16 nM. | ||
| M9277 | TG4-155 | Prostaglandin Receptor |
| TG4-155 is a brain penetrant prostaglandin EP2 specific antagonist, with a Ki of 9.9 nM. | ||
| M10632 | AM211 | Prostaglandin Receptor |
| AM-211; AM211 free acid | ||
| AM-211 is a novel and potent antagonist of the prostaglandin D2 receptor type 2, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. | ||
| M10634 | NE 52-QQ57 | GPR/FFAR |
| NE52QQ57 | ||
| NE 52-QQ57 is an orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 significantly inhibited the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2). | ||
| M10653 | Dehydroevodiamine | NF-κB |
| Dehydroevodiamine has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells. | ||
| M10791 | BAY-1316957 | Prostaglandin Receptor |
| BAY-1316957 is a potent, selective, orally active antagonist of the prostaglandin E2 receptor subtype 4 (EP4-R) against human EP4-R IC50 15.3 nM. BAY-1316957 has excellent drug metabolism and pharmacokinetic properties and can be used in the study of endometriosis. | ||
| M10795 | BGC-20-1531 free base | Prostaglandin Receptor |
| PGN 1531 free base | ||
| BGC-20-1531 (PGN 1531) free base is a potent selective prostaglandin EP4 receptor antagonists, pKB The value is 7.6. BGC-20-1531 free base has the potential to study migraines. | ||
| M10803 | Butaprost | Prostaglandin Receptor |
| Butaprost is a selective prostaglandin E receptor (EP2) agonist for murine EP2 receptors EC50 The value is 33 nM,Ki The value is 2.4 μM. Butaprost is less active against rodents EP1, EP3 and EP4 receptors. Butaprost mitigates fibrosis by obstructing TGF-β/Smad2 signaling. | ||
| M10807 | CJ-42794 | Prostaglandin Receptor |
| CJ-042794 | ||
| CJ-42794 is a selective prostaglandin receptor EP4 antagonist that inhibits [3H]-PGE2 binding to EP4 receptors with an average pKi of 8.5 and is more than 200 times more selective than EP1, EP2 and EP3. | ||
| M10827 | GSK726701A | Prostaglandin Receptor |
| GSK726701A is a partial agonist of prostaglandin E2 receptor 4 (EP4),pEC50is 7.4. | ||
| M10842 | KAG-308 | Prostaglandin Receptor |
| KAG-308 is an effective, selective, orallyable EP4 receptor (a subtype of prostaglandin E2 receptor) agonist that inhibits colitis, promotes tissue mucosal healing, and effectively inhibits the production of TNF-α. KAG-308 for human EP4 receptors Ki value and EC50 The values were 2.57 nM and 17 nM, respectively, which were more selective than EP1, EP2, EP3, and IP receptors. | ||
| M13722 | 15D-PGJ2 | PPAR |
| 15-Deoxy-Δ12,14-PGJ2; 15-deoxy-Δ12,14-prostaglandin J2 | ||
| 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. | ||
| M58604 | Vipoglanstat | PGE synthase |
| BI 1029539; GS-248; OX-MPI | ||
| Vipoglanstat (BI 1029539) is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50 = ≤0.5 nM in isolated human whole blood). Vipoglanstat reduces LPS-induced increases in the influx of neutrophils and levels of cytokines in bronchoalveolar lavage fluid (BALF), as well as the expression of PTGES, the gene encoding mPGES-1, Cox2, and Icam1 in the lung parenchyma, in a human PTGES knock-in mouse model of acute lung injury when administered at a dose of 30 mg/kg. | ||
| M15094 | Bromelain | Apoptosis |
| Bromelain, an anti-inflammatory compound derived from pineapple stem, acts by down-regulating plasma kinkinin, inhibiting prostaglandin E2 expression, degradation of receptors for advanced glycation end products, regulation of angiogenic biomarkers, and antioxidant activity upstream of the COX pathway. Can be used as a food additive. | ||
| M18309 | p-Hydroxy-cinnamic acid | Metabolite/Endogenous Metabolite |
| p-Hydroxy-cinnamic acid inhibits platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. | ||
| M20536 | Setipiprant (ACT-129968, KYTH-105) | Immunology/Inflammation |
| Setipiprant(ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1. | ||
| M22519 | Prostaglandin A2 | Metabolite/Endogenous Metabolite |
| PGA2; Medullin | ||
| Prostaglandin A2 (PGA2) is a endogenous metabolite derived from arachidonic acid, it plays a vital role in the induction of apoptosis. Prostaglandin A2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase. Prostaglandin A2 induces p53-dependent apoptosis. | ||
| M28496 | SC 51089 | Prostaglandin Receptor |
| SC 51089 is a selective antagonist of prostaglandin E2 EP1 receptor, with Kis of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 exhibits neuroprotective activity. | ||
| M28497 | SC 51089 free base | Prostaglandin Receptor |
| SC 51089 free base is a selective antagonist of prostaglandin E2 EP1 receptor, with Kis of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 free base exhibits neuroprotective activity. | ||
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