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PF-04217329

Cat. No. M8120

All AbMole products are for research use only, cannot be used for human consumption.

PF-04217329 Structure
Synonym:

PF-04217329

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Quality Control & Documentation
Biological Activity

PF-04217329 is a selective and potent prostaglandin EP2 receptor agonist. PF-04217329 is an ocular bioavailable isopropyl ester prodrug of CP-544326 (active acid metabolite).

Chemical Information
Molecular Weight 520.6
Formula C27H28N4O5S
CAS Number 1005549-94-9
Solubility (25°C) DMSO: 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gina M Yanochko, et al. Investigation of ocular events associated with taprenepag isopropyl, a topical EP2 agonist in development for treatment of glaucoma

[2] Ronald A Schachar, et al. Subclinical increased anterior stromal reflectivity with topical taprenepag isopropyl

[3] Ronald A Schachar, et al. A phase 2, randomized, dose-response trial of taprenepag isopropyl (PF-04217329) versus latanoprost 0.005% in open-angle glaucoma and ocular hypertension

[4] Ganesh Prasanna, et al. Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma

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