About 28 results found for searched term "PA22-2" (0.139 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43237 | PA22-2 | Others |
| PA22-2 (IKVAV sequence; Laminin A-chain fragment) is a biological active peptide. | ||
| M50881 | PA22-2 free acid | Others |
| PA22-2 (free acid) (Cys-Laminin A chain 2091-2108) is a peptide that supports neurite outgrowth and stimulates neuronal-like process formation. | ||
| M53444 | PA (224-233), Influenza | Anti-infection |
| PA (224-233), Influenza is a 10-aa peptide, a fragment of polymerase 2 protein in influenza A virus. | ||
| M3803 | Sotrastaurin | PKC |
| AEB071 | ||
| Sotrastaurin is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively. | ||
| M10567 | Acevaltrate | Sodium Channel |
| Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively. | ||
| M11449 | AG-024322 | COX |
| CS-1092 | ||
| Ag-024322 is a potent ATP-competitive pan-CDK inhibitor that inhibits THE Ki values of CDK1, CDK2, and CDK4 in the 1-3 nM range. Ag-024322 showed broad spectrum antitumor activity and clear target regulation in vivo. Ag-024322 induced apoptosis. | ||
| M13413 | JNJ-42226314 | MAGL |
| JNJ-42226314 is a competitive, highly selective and reversible inhibitor of non-covalent monoacylglycerol lipase (MAGL). The IC50s of JNJ-42226314 against human Hela cells, human PBMC, mouse brain and rat brain were 1.13 nM, 1.88 nM, 0.67 nM and 0.97 nM, respectively. | ||
| M14778 | Tafamidis meglumine | Transthyretin (TTR) |
| Fx-1006A | ||
| Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. | ||
| M15081 | Recombinant Human Prolactin/PRL (E.coli) | Cytokines and Growth Factors |
| Prolactin; PRL | ||
| Recombinant human prolactin was prepared by escherichia coli expression system and the target gene encoding Leu29-Cys227 was expressed. Accession # : P01236. | ||
| M15084 | Recombinant Mouse Sonic Hedgehog/Shh (E.coli) | Cytokines and Growth Factors |
| Sonic Hedgehog Protein; SHH; HHG-1; SHH | ||
| Recombinant mouse Sonic Hedgehog gene was prepared by escherichia coli expression system and the target gene encoding Cys25-Gly198 was expressed. Accession # : Q62226. | ||
| M21109 | Inobrodib | Epigenetic Reader Domain |
| CCS1477; CBP-IN-1; CBP/p300-IN-4 | ||
| Inobrodib (CCS1477, CBP-IN-1) is an orally active, potent and selective p300/CBP inhibitor. inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM and has a 170/130 fold selectivity compared to BRD4 with a Kd of 222 nM. Inobrodib (CCS1477) acts by inhibiting the expression and function of androgen receptor (AR) and by inhibiting c-Myc. | ||
| M21343 | Recombinant Mouse TIM-1/KIM-1/HAVCR (HEK293, C-6His) | Cytokines and Growth Factors |
| Hepatitis A virus cellular receptor 1 homolog; HAVcr-1 | ||
| Recombinant mouse hepatitis A virus cell receptor 1 homolog is produced by a mammalian expression system and the target gene encoding Tyr22Thr212 has a 6His tag at the C-terminus. Protein number: Q5QNS5. | ||
| M21389 | JNJ-55511118 | Others |
| JNJ-55511118 is an AMPA receptor negative regulator containing transmembrane AMPA receptor regulatory protein γ8 (TARP-γ8). 1 It inhibits glutamate-induced calcium flux in HEK293F cells that were cotransfected with TARP-γ8 and GluA1o, GluA1i, GluA2i, GluA3o, or GluA4o (IC50s = 11.22, 12.3, 7.41, 38.02, and 15.85 nM, respectively). | ||
| M24536 | Moxetumomab pasudotox | Drug-Linker Conjugates for ADC |
| CAT 8015; HA 22 Anti-Human CD22 Recombinant Antibody | ||
| Moxetumomab pasudotox (CAT 8015) is anti-CD22 immunotoxin containing an anti-CD22 Fv and Pseudomonas exotoxin. CD22 is a cell surface receptor expressed on a variety of malignant B-cells. Moxetumomab pasudotox can be used in the research of hairy cell leukemia (HCL). | ||
| M27787 | AMG-221 | Hydroxysteroid dehydrogenase |
| AMG-221 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a Ki of 12.8 nM in vitro biochemical scintillation proximity assay (SPA) and an IC50 of 10.1 nM in cell-based assays. AMG-221 can be used for the research of type 2 diabetes. | ||
| M28326 | Ro 6842262 | LPL Receptor |
| LPA1 receptor antagonist 1 | ||
| Ro 6842262 (LPA1 receptor antagonist 1) is an orally bioavailable, highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist with an IC50 of 25 nM. Ro 6842262 attenuates NHLF human lung fibroblast cell proliferation and contraction in vitro. Ro 6842262 also reduces plasma histamine levels in mouse LPA-challenge model. | ||
| M28951 | RS-102221 | 5-HT Receptor |
| RS-102221 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats. | ||
| M28976 | RS-102221 hydrochloride | 5-HT Receptor |
| RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats. | ||
| M28997 | NGB 2904 | Dopamine Receptor |
| NGB 2904 is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 antagonizes Quinpirole-stimulated mitogenesis. | ||
| M29121 | JNJ-56022486 | GluR |
| JNJ-56022486 is an orally active and potent negative AMPA receptor modulator (Ki=19 nM) selective for TARP-γ8. JNJ-56022486 is also a TARP-γ8 receptor antagonist, with blood brain barrier (BBB) permeability. JNJ-56022486 can be used for research of Epilepsy. | ||
| M30723 | LT175 | PPAR |
| LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties. | ||
| M42319 | DGKα-IN-6 | DGK |
| DGKα-IN-6 is a DGKα inhibitor with the IC50 of 1.377 nM, extracted from patent WO2022271650 (compound 143). | ||
| M42320 | DGKα-IN-7 | DGK |
| DGKα-IN-7 is a DGKα inhibitor with the IC50 of 6.225 nM, extracted from patent WO2022271684 (compound 100). | ||
| M49555 | JAK-IN-11 | JAK |
| JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment. | ||
| M58160 | 5-(N,N-Hexamethylene)-amiloride | Sodium Channel |
| Hexamethylene amiloride; HMA | ||
| 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively. | ||
| M56768 | sPLA2-X Inhibitor 31 | Phospholipase |
| sPLA2-X Inhibitor 31 is a selective secreted phospholipase A2 type X (sPLA2-X) inhibitor with IC50s of 26 nM, 310 nM, and 2230 nM for sPLA2-X, sPLA2-IIa, and sPLA2-V, respectively. | ||
| M56413 | JNJ28871063 hydrochloride | EGFR/HER2 |
| JNJ28871063 hydrochloride is an orally active, highly selective and ATP competitive pan-ErbB kinase inhibitor with IC50 values of 22 nM, 38 nM, and 21 nM for ErbB1, ErbB2, and ErbB4, respectively. | ||
| M58560 | Glucocerebrosides (Soy) | Others |
| Glucosylceramide (GluCer) is a major sphingolipid of plant tissue and, thus, abundant in nature and in dietary food sources. Soybean GluCer was comprised primarily (>98%) of ceramide with 4,8-sphingadiene (d18:2(delta4,delta8)) and alpha- hydroxypalmitic acid (h16:0); the remainder had the same backbone with h18:0, h20:0, h22:0 and h24:0 fatty acids. | ||
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