Ag-024322 is a potent ATP-competitive pan-CDK inhibitor that inhibits THE Ki values of CDK1, CDK2, and CDK4 in the 1-3 nM range. Ag-024322 showed broad spectrum antitumor activity and clear target regulation in vivo. Ag-024322 induced apoptosis.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related COX Products|
N-tert-Butyl-α-phenylnitrone is a nitrokeone-based free radical scavenger that forms a nitric oxide spin adduct. N-tert-Butyl-α-phenylnitrone inhibits the catalytic activity of COX2.
(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1), with IC50 of 1.4 μM。
Chebulagic acid is a dual inhibitor of COX-LOX extracted from the fruit. Has anti-inflammatory and anti-infective effects. Chebulagic acid is an M2(S31N) inhibitor and anti-influenza virus agent. Chebulagic acid also inhibits replication of the SARS-CoV-2 virus,EC50 The value is 9.76 μM.
Guaiacol is a phenolic compound, which inhibits LPS-stimulated COX-2 expression and NF-κB activation, with anti-inflammatory activity.
CAY10404 is one of the most selective inhibitors of COX-2 (IC50 = 1 nM) over COX-1.
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