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Recombinant Mouse TIM-1/KIM-1/HAVCR (Mammalian, C-6His)

Cat. No. M21343
Recombinant Mouse TIM-1/KIM-1/HAVCR (Mammalian, C-6His) Structure
Synonym:

Hepatitis A virus cellular receptor 1 homolog; HAVcr-1

Size Price Availability Quantity
10ug USD 112  USD112 In stock
50ug USD 350  USD350 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Genus: Mouse
Expression system: Mammalian
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Molecular weight: 21.8 KDa
Storage and Stability: Lyophilized proteins should be stored at <-20°C, although stable at room temperature for up to 3 weeks. Reconstituted protein solutions can be stored at 4-7°C for 2-7 days. Recombinant sample aliquots are stable for 3 months at <-20°C.


Bioactivity: TIM-1/KIM-1/HAVCR belongs to the immunoglobulin superfamily and has 305 amino acids (aa). It is expressed by stimulated T cells. TIM-1/KIM-1/HAVCR may play a role in the development of T helper cells and in the regulation of asthma and allergic diseases. It is a receptor for TIMD4. and may play a role in kidney injury and repair. Belongs to the T-cell and airway phenotypic regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), a hallmark of human asthma.





Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Mouse TIM-1/KIM-1/HAVCR (Mammalian, C-6His), Hepatitis A virus cellular receptor 1 homolog; HAVcr-1 supplier, Recombinant Proteins, inhibitors, activators


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