About 21 results found for searched term "Neuropeptide Receptor" (0.08 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6303 | JNJ-31020028 | Neuropeptide Receptor |
| JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. | ||
| M6969 | ML 154 | Others |
| ML 154 is a potent Neuropeptide S receptor antagonist. | ||
| M7629 | BIBP3226 TFA | Neuropeptide Receptor |
| BIBP3226 TFA is a novel, selective non-peptide neuropeptide Y Y1 receptor antagonist, with Ki values of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. | ||
| M8432 | CYM50769 | Neuropeptide Receptor |
| CYM50769 is a potent, specific antagonist of the Neuropeptide B and Neuropeptide W receptor, NPBWR1 (IC50 = 120 nM). | ||
| M8673 | MS0015203 | Others |
| MS15203 | ||
| MS0015203 is a potent and selective agonist of the neuropeptide receptor GPR171. | ||
| M9080 | Substance P | Neurokinin Receptor |
| Neurokinin P; SubstanceP | ||
| Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). | ||
| M10233 | ((Cys31,Nva34)-Neuropeptide Y (27-36))2 | Neuropeptide Receptor |
| BWX 46 | ||
| ((Cys31,Nva34)-Neuropeptide Y (27-36))2, also called BWX 46, is a neuropeptide Y (NPY) Y5 receptor selective agonist. | ||
| M10342 | [Leu31,Pro34]-NPY TFA (human,rat) | Neuropeptide Receptor |
| [Leu31,Pro34] Neuropeptide Y TFA | ||
| [Leu31,Pro34]-NPY TFA (human,rat) is a specific neuropeptide Y1 receptor agonist. | ||
| M11364 | α-MSH TFA | Melanocortin Receptor |
| alpha-MSH Trifluoroacetate; α-Melanocyte-stimulating hormone TFA, | ||
| As an endogenous neuropeptide, alpha-melanocyte-stimulating hormone (TFA) is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic effects. α-MSH TFA is a posttranslational derivative of preopelanocorticoid (POMC). | ||
| M13931 | Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA | CGRP Receptor |
| Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR). | ||
| M14024 | Substance P TFA | Neurokinin Receptor |
| Neurokinin P TFA | ||
| Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). | ||
| M14027 | Velneperit | Neuropeptide Receptor |
| S2367 | ||
| Velneperit (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist. Target: neuropeptide Y receptor Velneperit (S-2367) is a once-daily, oral, centrally acting, small molecule neuropeptide Y (NPY) Y5 receptor antagonist. | ||
| M25542 | JNJ-5207787 | Neuropeptide Receptor |
| JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50 values of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors. | ||
| M25543 | GR231118 | Neuropeptide Receptor |
| 1229U91; GW1229 | ||
| GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent, competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8). | ||
| M25544 | GR231118 TFA | Neuropeptide Receptor |
| 1229U91 TFA; GW1229 TFA | ||
| GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent, competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8). | ||
| M25555 | BIIE-0246 hydrochloride | Neuropeptide Receptor |
| AR-H 053591 hydrochloride | ||
| BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy. | ||
| M25556 | SHA 68 | Neuropeptide Receptor |
| SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50 values of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia. | ||
| M28638 | BIBP3226 | Neuropeptide Receptor |
| BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect. | ||
| M29873 | Lu AA33810 | Neuropeptide Receptor |
| Lu AA33810 is a potent and selective antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the human receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects. | ||
| M30680 | RTI-118 | Neuropeptide Receptor |
| RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve agent addiction including selectively decrease self-administration. | ||
| M31218 | Neuropeptide Y (3-36) (human, rat) | Neuropeptide Receptor |
| Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor. | ||
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