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GR231118

Cat. No. M25543

All AbMole products are for research use only, cannot be used for human consumption.

GR231118 Structure
Synonym:

1229U91; GW1229

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Quality Control & Documentation
Biological Activity

GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent, competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8).

Chemical Information
Molecular Weight 2352.74
Formula C110H170N34O24
CAS Number 158859-98-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Iain R Tough, et al. J Pharmacol Exp Ther. Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa

[2] C Mollereau, et al. Br J Pharmacol. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226

[3] Y Dumont, et al. Br J Pharmacol. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors

[4] A P Serone, et al. J Cardiovasc Pharmacol. Role of NPY Y1 receptors in cardiovascular control in the conscious rabbit

[5] E M Parker, et al. Eur J Pharmacol. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists

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Keywords: GR231118, 1229U91; GW1229 supplier, Neuropeptide Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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