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JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50 values of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors.
| Molecular Weight | 510.67 |
| Formula | C32H38N4O2 |
| CAS Number | 683746-68-1 |
| Form | Solid |
| Storage | Powder -20°C |
[4] Gopi Kumar Mittapalli, et al. Bioorg Med Chem Lett. Ligands of the neuropeptide Y Y2 receptor
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