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Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). SP induces internalization of the NK1-R both in transfected epithelial cells.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 1347.63 |
| Formula | C63H98N18O13S |
| CAS Number | 33507-63-0 |
| Purity | 100.00% |
| Solubility | Water: ≥ 15 mg/mL |
| Storage | at -20°C |
Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.
Grady EF, et al. Mol Biol Cell. 1995 May;6(5):509-24. PMID: 7545030.
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[Leu31,Pro34]-NPY TFA (human,rat) is a specific neuropeptide Y1 receptor agonist. |
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Vapreotide acetate (BMY-41606 acetate; RC160 acetate) is a neurokinin-1 (NK1) receptor antagonist with IC50 value of 330 nM. |
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Ibodutant (MEN15596) is a potent and selective tachykinin NK2 receptor antagonist with a pKi of 10.1. |
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SCH-619734 is an orally bioavailable, centrally-acting, selective neurokinin 1 receptor (NK1-receptor) antagonist with a Ki of 0.66 nM. |
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