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Substance P

Cat. No. M9080
Substance P Structure
Synonym:

Neurokinin P; SubstanceP

Size Price Availability Quantity
5mg USD 132  USD132 In stock
10mg USD 238  USD238 In stock
25mg USD 530  USD530 In stock
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Quality Control & Documentation
Biological Activity

Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). SP induces internalization of the NK1-R both in transfected epithelial cells.

Chemical Information
Molecular Weight 1347.63
Formula C63H98N18O13S
CAS Number 33507-63-0
Solubility (25°C) Water: ≥ 15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Grady EF, et al. Mol Biol Cell. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.

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Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist.

Substance P (7-11)

Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.

[Sar9, Met(O2)11]-Substance P TFA

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK1 receptor selective agonist.

[bAla8]-Neurokinin A(4-10)

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

[Sar9, Met(O2)11]-Substance P

[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.

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Keywords: Substance P, Neurokinin P; SubstanceP supplier, Neurokinin Receptor, inhibitors, activators


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