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Substance P

Cat. No. M9080
Substance P Structure
Synonym:

Neurokinin P; SubstanceP

Size Price Availability Quantity
5mg USD 123.3  USD137 In stock
10mg USD 225  USD250 In stock
25mg USD 508.5  USD565 In stock
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Quality Control
Biological Activity

Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). SP induces internalization of the NK1-R both in transfected epithelial cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1347.63
Formula C63H98N18O13S
CAS Number 33507-63-0
Purity 100.00%
Solubility Water: ≥ 15 mg/mL
Storage at -20°C
References

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.
Grady EF, et al. Mol Biol Cell. 1995 May;6(5):509-24. PMID: 7545030.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Substance P, Neurokinin P; SubstanceP supplier, Neurokinin Receptor, inhibitors

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