[Leu31,Pro34]-NPY TFA (human,rat) is a specific neuropeptide Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA (30 pmol; microinjected into paraventricular nucleus) increases food intake in the rats (350±400 g).
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|CAS Number||132699-73-1 (free base)|
|Solubility||Water 45 mg/mL|
|Storage||-20°C, dry, sealed|
2-36[K4,RYYSA(19-23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake
K McCrea, et al. Regul Pept. 2000 Feb 8;87(1-3):47-58. PMID: 10710288.
Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226
A Kask, et al. Br J Pharmacol. 1998 Aug;124(7):1507-15. PMID: 9723965.
[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist
J Fuhlendorff, et al. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6. PMID: 2153286.
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