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[Leu31,Pro34]-NPY TFA (human,rat)

Cat. No. M10342
[Leu31,Pro34]-NPY TFA (human,rat) Structure
Synonym:

[Leu31,Pro34] Neuropeptide Y TFA

Size Price Availability
10mg USD 600.3  USD667 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

[Leu31,Pro34]-NPY TFA (human,rat) is a specific neuropeptide Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA (30 pmol; microinjected into paraventricular nucleus) increases food intake in the rats (350±400 g).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 4354.76
Formula C191H285F3N54O58S
CAS Number 132699-73-1 (free base)
Purity >99%
Solubility Water 45 mg/mL
Storage -20°C, dry, sealed
References

2-36[K4,RYYSA(19-23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake
K McCrea, et al. Regul Pept. 2000 Feb 8;87(1-3):47-58. PMID: 10710288.

Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226
A Kask, et al. Br J Pharmacol. 1998 Aug;124(7):1507-15. PMID: 9723965.

[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist
J Fuhlendorff, et al. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6. PMID: 2153286.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: [Leu31,Pro34]-NPY TFA (human,rat), [Leu31,Pro34] Neuropeptide Y TFA supplier, Neurokinin Receptor, inhibitors

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