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Substance P TFA

Cat. No. M14024
Substance P TFA Structure
Synonym:

Neurokinin P TFA

Size Price Availability Quantity
5mg USD 130  USD130 In stock
10mg USD 240  USD240 In stock
25mg USD 430  USD430 In stock
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Quality Control & Documentation
Biological Activity

Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

Chemical Information
Molecular Weight 1461.67
CAS Number 148470-19-3
Solubility (25°C) Water 90 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Floriane Pailleux, et al. Evaluation of multiple reaction monitoring cubed for the analysis of tachykinin related peptides in rat spinal cord using a hybrid triple quadrupole-linear ion trap mass spectrometer

[2] Francis Beaudry, et al. Identification, characterization and quantification of specific neuropeptides in rat spinal cord by liquid chromatography electrospray quadrupole ion trap mass spectrometry

[3] N S Cheung, et al. Identification of multiple tachykinins in bovine adrenal medulla using an improved chromatographic procedure

[4] W Neugebauer, et al. Synthesis and immunological evaluation of N-terminal, noncrossreactive tachykinin antigens

[5] H Yajima, et al. Current contributions of peptide synthesis to studies on brain-gut-skin triangle peptides

Related Neurokinin Receptor Products
Spantide II

Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist.

Substance P (7-11)

Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.

[Sar9, Met(O2)11]-Substance P TFA

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK1 receptor selective agonist.

[bAla8]-Neurokinin A(4-10)

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

[Sar9, Met(O2)11]-Substance P

[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.

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Keywords: Substance P TFA, Neurokinin P TFA supplier, Neurokinin Receptor, inhibitors, activators


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