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SHA 68 

Cat. No. M25556
SHA 68  Structure
Size Price Availability Quantity
10mg USD 165  USD165 In stock
50mg USD 650  USD650 In stock
100mg USD 1150  USD1150 In stock
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Biological Activity

SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50 values of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.

Chemical Information
Molecular Weight 445.49
Formula C26H24FN3O3
CAS Number 847553-89-3
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Allison Zarkin, et al. Pharmaceuticals (Basel). Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core

[2] Claudio Trapella, et al. J Med Chem. Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68)

[3] Chiara Ruzza, et al. Peptides. Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68

[4] Remo Guerrini, et al. Med Res Rev. Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor

[5] Naoe Okamura, et al. J Pharmacol Exp Ther. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor

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Keywords: SHA 68  supplier, Neuropeptide Receptor, inhibitors, activators

 
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