About 30 results found for searched term "NOS" (0.004 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1670 | Belinostat | HDAC |
| PXD101; PX105684 | ||
| Belinostat (PXD101) is a novel HDAC inhibitor with an IC50 of 27 nM. | ||
| M6229 | Kanamycin sulfate | Antibiotic |
| Kanamycin A monosulfate | ||
| Kanamycin sulfate is an aminoglycoside antibiotic that acts as a bacteriostatic agent by binding to the bacterial 30S ribosome. | ||
| M1730 | Givinostat hydrochloride monohydrate | HDAC |
| ITF-2357 hydrochloride monohydrate | ||
| ITF2357 (Givinostat, Gavinostat) is a histone deacetylase inhibitor. The IC50 values for maize HDAC preparations HD2, HD-1B and HD-1A are 10, 7.5 and 16 nM respectively. | ||
| M1748 | LBH589 (Panobinostat) | HDAC |
| NVP-LBH589, Panobinostat | ||
| LBH589 (Panobinostat) is a novel broad-spectrum HDAC inhibitor for MOLT-4 and Reh cells with IC50 of 5 and 20 nM, respectively. | ||
| M1778 | SB939 | HDAC |
| Pracinostat | ||
| SB939 is a novel potent and orally active histone deacetylase with high tumor exposure and efficacy in mouse models of colorectal cancer. | ||
| M1780 | Vorinostat | HDAC |
| SAHA; Zolinza; MK-0683; Suberoylanilide hydroxamic acid | ||
| Vorinostat (SAHA, Zolinza, MK-0683) is a selective and potent histone deacetylase (HDAC) inhibitor with the IC50 value of 10 nM for HDAC-1. | ||
| M1790 | MGCD0103 | HDAC |
| Mocetinostat | ||
| MGCD0103 is a novel HDAC inhibitor, highly specific for classes I and IV HDACs, with IC50 of 0.15, 0.29 and 1.66 μM for HDAC 1, HDAC 2 and HDAC 3 respectively. | ||
| M1791 | Entinostat (MS-275) | HDAC |
| SNDX-275, MS-27-275 | ||
| Entinostat (MS-275) is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively. | ||
| M1813 | PCI-24781 | HDAC |
| Abexinostat; CRA-024781 | ||
| PCI-24781 is a novel and potent histone deacetylase (HDAC) inhibitor with IC50 value of 0.43 to 2.7 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M9217 | Givinostat | HDAC |
| ITF2357 | ||
| Givinostat (ITF-2357) is an HDAC inhibitor with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively. | ||
| M1993 | Droxinostat | HDAC |
| NS 41080 | ||
| Droxinostat is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively. | ||
| M2111 | CUDC-907 | HDAC |
| fimepinostat | ||
| CUDC-907 is a potent, orally-available small molecule dual PI3K and HDAC inhibitor. | ||
| M2119 | JNJ-26481585 | HDAC |
| Quisinostat | ||
| JNJ-26481585 (Quisinostat) is a novel second-generation class I HDAC inhibitor. | ||
| M2123 | Rocilinostat | HDAC |
| ACY-1215; Ricolinostat | ||
| Rocilinostat (ACY-1215) is an HDAC6-selective inhibitor with IC50 of 5 nM. | ||
| M2175 | Palonosetron hydrochloride | 5-HT Receptor |
| Palonosetron hydrochloride is a novel antiemetic 5-HT3-receptor antagonist. | ||
| M2292 | Cytarabine | DNA/RNA Synthesis |
| Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C | ||
| Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. | ||
| M2849 | Microcystin-LR | Phosphatase |
| Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa) | ||
| Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. | ||
| M2888 | Noscapine hydrochloride | Microtubule |
| Noscapine, a phthalideisoquinoline alkaloid constituting 1–10% of the alkaloid content of opium, has been used as a cough suppressant. | ||
| M2914 | Paromomycin Sulfate | Antibiotic |
| Aminosidine sulfate; Paromomycin sulfate salt | ||
| Paromomycin Sulfate is an aminoglycoside antibioticis inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA. | ||
| M2995 | Salinosporamide A | Proteasome |
| (-)-Salinosporamide A; ML 858; NPI 0052; Marizomib | ||
| Salinosporamide A (NPI-0052, Marizomib) is a novel marine derived proteasome inhibitor which inhibits CT-L, C-L, and T-L proteasome activities in human erythrocyte-derived 20S proteasomes with EC50 of 3.5 nM, 430 nM, 28 nM. | ||
| M3017 | Sodium 4-Aminosalicylate | NF-κB |
| 4-Aminosalicylic acid | ||
| Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging. | ||
| M3292 | Adenosine | Metabolite/Endogenous Metabolite |
| Adenine riboside; D-Adenosine | ||
| Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. | ||
| M3355 | Didanosine | Reverse Transcriptase |
| 2',3'-Dideoxyinosine; ddI | ||
| Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. | ||
| M3533 | Spectinomycin hydrochloride | Antibiotic |
| Actinospectacin | ||
| Spectinomycin hydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis. | ||
| M3894 | Rutin | Amyloid |
| Rutoside; Quercetin 3-O-rutinoside | ||
| Rutin is a flavonol glycoside found in many plants including buckwheat, tobacco, forsythia, hydrangea, viola, etc., which possesses healthy effects for human. | ||
| M3904 | Pulchinenoside A | GluR |
| Anemoside A3 | ||
| Pulchinenoside can inhibit abnormal proliferation of synovial membrane by modulating Wnt pathway of RA rats.Pulchinenoside may inhibit the FLS proliferation in AA rats by increase in FLS apoptosis. | ||
| M3905 | Anemoside B4 | Others |
| Chinensioside A, Pulchinenoside C, Pulchinenoside B4 | ||
| Pulchinenoside C (Anemoside B4) is a natural Pulchinenoside B4, which has many biological effects, such as anti-tumor, neuroprotective, anti-angiogenic and other activities. | ||
| M3926 | Cynaroside | Akt |
| Luteolin-7-O-D-glucopyranoside | ||
| Cynaroside is a flavone, a flavonoid-like chemical compound. It is a 7-O-glucoside of luteolin. | ||
| M3940 | Ginsenoside Rg1 | Amyloid |
| G-Rg1; Panaxoside Rg1 | ||
| Ginsenoside Rg1 is part of a class of triterpene saponins and steroid glycosides. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. It is found exclusively in the plant genus Panax, or ginseng. | ||
| M3987 | Ginsenoside Rb1 | Sodium Channel |
| Gynosaponin C; Gypenoside III | ||
| Ginsenoside Rb1 is an ingredient in the Chinese medicine Panax ginseng. Ginsenoside inhibition Na, K-ATPase++ activityIC50 6.3±1.0 μM. Ginsenoside Rb1 also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. | ||
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