About 30 results found for searched term "NOS" (0.003 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1670 | Belinostat | HDAC |
| PXD101; PX105684 | ||
| Belinostat (PXD101) is a novel HDAC inhibitor with an IC50 of 27 nM. | ||
| M6229 | Kanamycin sulfate | Antibiotic |
| Kanamycin A monosulfate | ||
| Kanamycin sulfate is an aminoglycoside antibiotic that acts as a bacteriostatic agent by binding to the bacterial 30S ribosome. | ||
| M58517 | 2'-Deoxyinosine | Metabolite/Endogenous Metabolite |
| 2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability. | ||
| M1730 | Givinostat hydrochloride monohydrate | HDAC |
| ITF-2357 hydrochloride monohydrate | ||
| ITF2357 (Givinostat, Gavinostat) is a histone deacetylase inhibitor. The IC50 values for maize HDAC preparations HD2, HD-1B and HD-1A are 10, 7.5 and 16 nM respectively. | ||
| M1748 | LBH589 (Panobinostat) | HDAC |
| NVP-LBH589, Panobinostat | ||
| LBH589 (Panobinostat) is a novel broad-spectrum HDAC inhibitor for MOLT-4 and Reh cells with IC50 of 5 and 20 nM, respectively. | ||
| M1778 | SB939 | HDAC |
| Pracinostat | ||
| SB939 is a novel potent and orally active histone deacetylase with high tumor exposure and efficacy in mouse models of colorectal cancer. | ||
| M1780 | Vorinostat | HDAC |
| SAHA; Zolinza; MK-0683; Suberoylanilide hydroxamic acid | ||
| Vorinostat (SAHA, Zolinza, MK-0683) is a selective and potent histone deacetylase (HDAC) inhibitor with the IC50 value of 10 nM for HDAC-1. | ||
| M1790 | MGCD0103 | HDAC |
| Mocetinostat | ||
| MGCD0103 is a novel HDAC inhibitor, highly specific for classes I and IV HDACs, with IC50 of 0.15, 0.29 and 1.66 μM for HDAC 1, HDAC 2 and HDAC 3 respectively. | ||
| M1791 | Entinostat (MS-275) | HDAC |
| SNDX-275, MS-27-275 | ||
| Entinostat (MS-275) is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively. | ||
| M1813 | PCI-24781 | HDAC |
| Abexinostat; CRA-024781 | ||
| PCI-24781 is a novel and potent histone deacetylase (HDAC) inhibitor with IC50 value of 0.43 to 2.7 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M9217 | Givinostat | HDAC |
| ITF2357 | ||
| Givinostat (ITF-2357) is an HDAC inhibitor with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively. | ||
| M1993 | Droxinostat | HDAC |
| NS 41080 | ||
| Droxinostat is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively. | ||
| M2111 | Fimepinostat | HDAC |
| CUDC-907 | ||
| Fimepinostat (CUDC-907) is a potent, orally-available small molecule dual PI3K and HDAC inhibitor, with IC50 values of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10, respectively. | ||
| M2119 | JNJ-26481585 | HDAC |
| Quisinostat | ||
| JNJ-26481585 (Quisinostat) is a novel second-generation class I HDAC inhibitor. | ||
| M2123 | Rocilinostat | HDAC |
| ACY-1215; Ricolinostat | ||
| Rocilinostat (ACY-1215) is an HDAC6-selective inhibitor with IC50 of 5 nM. | ||
| M2175 | Palonosetron hydrochloride | 5-HT Receptor |
| Palonosetron hydrochloride is a novel antiemetic 5-HT3-receptor antagonist. | ||
| M2292 | Cytarabine | DNA/RNA Synthesis |
| Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C | ||
| Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. | ||
| M2849 | Microcystin-LR | Phosphatase |
| Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa) | ||
| Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. | ||
| M2888 | Noscapine hydrochloride | Microtubule |
| Noscapine, a phthalideisoquinoline alkaloid constituting 1–10% of the alkaloid content of opium, has been used as a cough suppressant. | ||
| M2914 | Paromomycin Sulfate | Antibiotic |
| Aminosidine sulfate; Paromomycin sulfate salt | ||
| Paromomycin Sulfate is an aminoglycoside antibioticis inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA. | ||
| M2995 | Salinosporamide A | Proteasome |
| (-)-Salinosporamide A; ML 858; NPI 0052; Marizomib | ||
| Salinosporamide A (NPI-0052, Marizomib) is a novel marine derived proteasome inhibitor which inhibits CT-L, C-L, and T-L proteasome activities in human erythrocyte-derived 20S proteasomes with EC50 of 3.5 nM, 430 nM, 28 nM. | ||
| M3017 | Sodium 4-Aminosalicylate | NF-κB |
| 4-Aminosalicylic acid | ||
| Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging. | ||
| M3292 | Adenosine | Metabolite/Endogenous Metabolite |
| Adenine riboside; D-Adenosine | ||
| Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. | ||
| M3340 | Aciclovir | Anti-infection |
| Acyclovir; Acycloguanosine | ||
| Aciclovir is a synthetic nucleoside analogue active against herpesviruses. | ||
| M3355 | Didanosine | Reverse Transcriptase |
| 2',3'-Dideoxyinosine; ddI | ||
| Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. | ||
| M3533 | Spectinomycin hydrochloride | Antibiotic |
| Actinospectacin | ||
| Spectinomycin hydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis. | ||
| M3894 | Rutin | Amyloid |
| Rutoside; Quercetin 3-O-rutinoside | ||
| Rutin is a flavonol glycoside found in many plants including buckwheat, tobacco, forsythia, hydrangea, viola, etc., which possesses healthy effects for human. | ||
| M3904 | Pulchinenoside A | GluR |
| Anemoside A3 | ||
| Pulchinenoside can inhibit abnormal proliferation of synovial membrane by modulating Wnt pathway of RA rats.Pulchinenoside may inhibit the FLS proliferation in AA rats by increase in FLS apoptosis. | ||
| M3905 | Anemoside B4 | Others |
| Chinensioside A, Pulchinenoside C, Pulchinenoside B4 | ||
| Pulchinenoside C (Anemoside B4) is a natural Pulchinenoside B4, which has many biological effects, such as anti-tumor, neuroprotective, anti-angiogenic and other activities. | ||
| M3926 | Cynaroside | Akt |
| Luteolin-7-O-D-glucopyranoside | ||
| Cynaroside is a flavone, it is a 7-O-glucoside of luteolin that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. | ||
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