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Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. Extracellular adenosine concentrations from normal cells are approximately 300 nM; however, in response to cellular damage (e.g. in inflammatory or ischemic tissue), these concentrations are quickly elevated (600–1,200 nM). Thus, in regard to stress or injury, the function of adenosine is primarily that of cytoprotection preventing tissue damage during instances of hypoxia, ischemia, and seizure activity. Activation of A2A receptors produces a constellation of responses that in general can be classified as anti-inflammatory.
| Molecular Weight | 267.24 |
| Formula | C10H13N5O4 |
| CAS Number | 58-61-7 |
| Solubility (25°C) | DMSO 12 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Shuli Man, et al. Potential and promising anticancer drugs from adenosine and its analogs
[2] Robert W Greene, et al. The adenosine-mediated, neuronal-glial, homeostatic sleep response
[3] J Novotn. Adenosine and its role in physiology
[4] Mehdi Kazemzadeh-Narbat, et al. Adenosine-associated delivery systems
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