About 30 results found for searched term "NC9" (0.026 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2039 | Baricitinib | JAK |
| INCB28050, LY3009104 | ||
| Baricitinib (INCB28050) is an oral JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, respectively. | ||
| M2720 | IDO5L | IDO |
| INCB14943; INCB024360 analogue | ||
| IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM. | ||
| M3107 | UNC1999 | EZH2 |
| UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. | ||
| M3109 | UNC669 | Epigenetic Reader Domain |
| UNC669 is a potent and selective MBT (malignant brain tumor) inhibitor with IC50 of 6 μM for L3MBTL1, 5- and 11-fold selective over L3MBTL3 and L3MBTL4. | ||
| M3194 | Nocodazole | Src-bcr-Abl |
| Oncodazole；R17934 | ||
| Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. | ||
| M3942 | Cephalotaxine | Anti-infection |
| (-)-Cephalotaxine; ZINC19795976 | ||
| Cephalotaxine is a benzazepine alkaloid isolated from Cephalotaxus harringtonia. | ||
| M4813 | UNC0379 | Histone Methyltransferase |
| UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM. | ||
| M4884 | Dalvance | Antibiotic |
| Dalbavancin; BI 397; MDL 63397 | ||
| Dalbavancin (Zeven, BI 397, MDL 63397) is a lipopeptide antibiotic with bactericidal activity against Gram-positive bacteria, such as a variety of staphylococcus. | ||
| M5315 | Baricitinib phosphate | JAK |
| INCB028050; LY3009104 | ||
| Baricitinib phosphate(INCB 028050; LY 3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. | ||
| M7033 | NNC 05-2090 hydrochloride | Others |
| NNC 05-2090 hydrochloride is a gABA uptake inhibitor; moderately BGT-1 selective. | ||
| M7034 | NNC 55-0396 dihydrochloride | Calcium Channel |
| NNC 55-0396 dihydrochloride is a highly selective Ca 2+ channel blocker (T-type). | ||
| M7459 | UNC 926 hydrochloride | Others |
| UNC 926 hydrochloride is a l3MBTL1 domain inhibitor. | ||
| M8370 | NCTT-956 | Others |
| NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC50 of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. | ||
| M8876 | Itacitinib | JAK |
| INCB039110 | ||
| Itacitinib (INCB039110) is a potent, selective JAK1 inhibitor with an IC50 value of 2 nM for human JAK1. It has oral bioactivity and potential anti-tumor activity. | ||
| M9827 | Recombinant Human Oncostatin M Protein (HEK293) | Cytokines and Growth Factors |
| OSM | ||
| Oncostatin M (HEK293) is also known as OSM, is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. | ||
| M10187 | Zinc Protoporphyrin | Heme oxygenase |
| ZnPPIX; zinc protoporphyrin IX; Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9 | ||
| Zinc Protoporphyrin is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. | ||
| M11019 | UNC6934 | Histone Methyltransferase |
| UNC6934 is a chemical probe that targets the PWWP domain of NSD2 and locates kernels. | ||
| M11238 | UNC569 | TAM Receptor |
| UNC569 is a potent, reversible, ATP-competitive and orally active Mer kinase inhibitor with IC50 of 2.9 nM and Ki of 4.3 nM. UNC569 also inhibited Axl and Tyro3 with IC50 of 37 nM and 48 nM, respectively. | ||
| M11273 | UNC5293 | Others |
| UNC5293 is a potent and selective inhibitor of MERTK (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective for Axl, Tyro3 and Flt3. UNC5293 showed excellent pharmacokinetic properties in mice. | ||
| M11288 | NCGC00229600 | Others |
| NCGC00229600 is an allosteric reverse agonist of TSHR. NCGC00229600 inhibits TSH and stimulates antibody activation of internally expressed TSHRs in Graves' disease. | ||
| M13822 | INCB054329 | Epigenetic Reader Domain |
| INCB054329 is a potent BET inhibitor. | ||
| M20696 | Rubitecan | Topoisomerase |
| 9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000 | ||
| Rubitecan is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity. | ||
| M21098 | INCB13739 | Hydroxysteroid dehydrogenase |
| INCB13739 is an orally effective, selective and tissue-specific 11β-HSD1 (11β-hydroxysteroid dehydrogenase 1) inhibitor with IC50 values of 3.2 nM (11β-HSD1 enzyme) and 1.1 nM (11β-HSD1 PBMC), respectively.INCB13739 can be used in type 2 diabetes mellitus (T2DM) and obesity studies. | ||
| M22483 | Linvencorvir (RG7907) | Antibiotic |
| RG7907 | ||
| Linvencorvir (RG7907) is a hepatitis B virus (HBV) core protein allosteric modulator, it is an antiviral agent. | ||
| M22521 | ZINC00640089 | Akt |
| ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. | ||
| M24626 | Fletikumab | IL Receptor/Related |
| NNC 0109-0012 | ||
| Fletikumab (NNC0109-0012) is a monoclonal antibody targeting to IL-20. Fletikumab can be used for inflammation research, such as rheumatoid arthritis. | ||
| M24696 | Ascrinvacumab | ALK |
| Anti-ACVRL1/ALK-1 Reference Antibody; PF-03446962 | ||
| Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC). | ||
| M25048 | Feladilimab | Others |
| Anti-ICOS/CD278 Reference Antibody; GSK3359609 | ||
| Feladilimab (Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609) is humanized IgG4 anti-ICOS agonist monoclonal antibody. Feladilimab binds to ICOS-expressing T cells. Feladilimab has the potential for the research of cancer. | ||
| M25396 | Recombinant Human Oncostatin M (OSM) (E. coli, 209aa) | Cytokines and Growth Factors |
| OSM | ||
| Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. ED50 < 10.0 ng/ml, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg. | ||
| M27661 | SC-9 | PKC |
| NCM 119 | ||
| SC-9 is a PKC activator in the presence of Ca2+. | ||
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