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Itacitinib

Cat. No. M8876
Itacitinib Structure
Synonym:

INCB039110

Size Price Availability Quantity
2mg USD 94.5  USD105 In stock
5mg USD 126  USD140 In stock
25mg USD 504  USD560 In stock
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Quality Control
Biological Activity

Itacitinib, also known as INCB39110 or INCB039110, is a potent JAK1 tyrosine kinase inhibitor, which is currently in Phase II trials for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.

INCB039110 produced significant improvements in sPGA, demonstrating proof of concept in chronic plaque psoriasis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 553.51
Formula C26H23F4N9O
CAS Number 1334298-90-6
Purity 99.53%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis.
Mascarenhas JO, et al. Haematologica. 2017 Feb;102(2):327-335. PMID: 27789678.

A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis.
Bissonnette R, et al. J Dermatolog Treat. 2016 Jan 14;1-7. PMID: 26769332.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Itacitinib, INCB039110 supplier, JAK, inhibitors

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