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NCGC00229600

Cat. No. M11288

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NCGC00229600 Structure

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Biological Activity

NCGC00229600 is an allosteric reverse agonist of TSHR. NCGC00229600 inhibits TSH and stimulates antibody activation of internally expressed TSHRs in Graves' disease.

Chemical Information
Molecular Weight 479.56956
Formula C30H29N3O3
CAS Number 1338824-20-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Adina F Turcu, et al. J Clin Endocrinol Metab. A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy

[2] Susanne Neumann, et al. Thyroid. A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts

[3] Susanne Neumann, et al. J Clin Endocrinol Metab. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor

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Keywords: NCGC00229600 supplier, inhibitors, activators

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