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Zinc Protoporphyrin

Cat. No. M10187
Zinc Protoporphyrin Structure
Synonym:

ZnPPIX; zinc protoporphyrin IX

Size Price Availability Quantity
2mg USD 100  USD100 In stock
5mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Zinc Protoporphyrin is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor.

Product Citations
Chemical Information
Molecular Weight 626.02
Formula C34H32N4O4Zn
CAS Number 15442-64-5
Solubility (25°C) DMSO 50 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dongdong Li, et al. Life Sci. Heme oxygenase-1 alleviated non-alcoholic fatty liver disease via suppressing ROS-dependent endoplasmic reticulum stress

[2] Xinnong Liu, et al. Oxid Med Cell Longev. Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway

[3] Min-Young Kwon, et al. Oncotarget. Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

[4] Dominika Nowis, et al. BMC Cancer. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice

[5] Xing Rong, et al. Zhonghua Er Ke Za Zhi. Effects of hemoglobin oxygenase-1 inhibitor zinc protoporphyrin IX on acute viral myocarditis in mice

[6] Kaeko Hirai, et al. Int J Cancer. Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice

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Keywords: Zinc Protoporphyrin, ZnPPIX; zinc protoporphyrin IX supplier, Heme oxygenase, inhibitors, activators


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