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Hemin is an iron-containing porphyrin. Hemin strongly increased both expression and activity of HMOX after 4 and 12 h, respectively. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons.
In vivo, following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules.
| Molecular Weight | 651.94 |
| Formula | C34H32ClFeN4O4 |
| CAS Number | 16009-13-5 |
| Solubility (25°C) | 1M NaOH: 6 mg/mL (ultrasonic and adjust pH to 12 with NaOH) DMSO ≥ 6 mg/mL (Need ultrasonic and warming) |
| Storage | 4°C, protect from light, sealed |
[3] Aliye Uc, et al. Hemin induces active chloride secretion in Caco-2 cells
| Related Heme oxygenase Products |
|---|
| Heme Oxygenase-1-IN-1 hydrochloride
Heme Oxygenase-1-IN-1 hydrochloride (Compound 2) is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 250 nM. |
| Heme Oxygenase-1-IN-1
Heme Oxygenase-1-IN-1 (Compound 2) is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 250 nM. |
| Coniferaldehyde
Coniferaldehyde (Ferulaldehyde) is a potent inducer of heme oxygenase-1 (HO-1) with anti-inflammatory effects. In RAW264.7 macrophages, Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/βII/Nrf-2/HO-1-dependent pathway. |
| Zinc Protoporphyrin
Zinc Protoporphyrin is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. |
| Tin protoporphyrin IX dichloride
Tin protoporphyrin IX dichloride is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model. |
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