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Hemin chloride

Cat. No. M9092
Hemin chloride Structure
Synonym:

Hemin

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500mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Hemin is an iron-containing porphyrin. Hemin strongly increased both expression and activity of HMOX after 4 and 12 h, respectively. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons.

In vivo, following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules.

Chemical Information
Molecular Weight 651.94
Formula C34H32ClFeN4O4
CAS Number 16009-13-5
Solubility (25°C) 1M NaOH: 6 mg/mL (ultrasonic and adjust pH to 12 with NaOH)
DMSO ≥ 6 mg/mL (Need ultrasonic and warming)
Storage 4°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Natalie E Palmaers, et al. Distinct Mechanisms Account for In Vitro Activation and Sensitization of TRPV1 by the Porphyrin Hemin

[2] Muhan Zhang, et al. Effect of myoglobin, hemin, and ferric iron on quality of chicken breast meat

[3] Aliye Uc, et al. Hemin induces active chloride secretion in Caco-2 cells

[4] A U Orjih, et al. Hemin lyses malaria parasites

[5] R L Aft, et al. Hemin-mediated DNA strand scission

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Keywords: Hemin chloride, Hemin supplier, Heme oxygenase, inhibitors, activators


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