About 30 results found for searched term "K-41" (0.031 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2734 | GSK2606414 | PERK |
| GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. | ||
| M2764 | Ibudilast | PDE |
| KC-404; AV-411; MN-166 | ||
| Ibudilast is a potent PDE4 inhibitor for PDE4A with IC50 of 54 nM. | ||
| M2850 | Midostaurin | PKC |
| PKC412 | ||
| Midostaurin (pkc412) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM. | ||
| M3404 | URB597 | FAAH |
| KDS-4103 | ||
| URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. | ||
| M5077 | (S)-(-)-BAY K 8644 | Calcium Channel |
| (S)-(-)-Bay-K-8644; (-)-BAY-R-5417; (-)-BAY-K-8644 | ||
| (S)-(-)-BAY K 8644 is a Ca2+ channel activator; L-type Ca2+ channel activator. | ||
| M6025 | Tranilast | Angiotensin Receptor |
| MK 341; SB 252218 | ||
| Tranilast is an antiallergic agent. | ||
| M6044 | Uprosertib (GSK2141795) | Akt |
| GSK795; Uprosertib | ||
| Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1). | ||
| M6549 | BYK 204165 | PARP |
| BYK 204165 is a selective PARP-1 inhibitor. | ||
| M6773 | GSK 4112 | REV-ERB |
| SR6452 | ||
| GSK 4112 is a selective Rev-Erbα agonist with an EC50 value of 0.4 μM, which can be used to explore the function of Rev-erbα in transcriptional repression, biological regulation of circadian rhythms and metabolic pathways. | ||
| M7304 | SKF 97541 | Others |
| SKF 97541 is a extremely potent GABA B agonist. | ||
| M8977 | MK-4101 | Smo |
| MK-4101 is a novel SMO antagonist of the Hedgehog Pathway. | ||
| M10682 | TAK-041 | GPR/FFAR |
| NBI-1065846 | ||
| TAK-041 is a first-in-class, selective GPR139 agonist with an EC50 of 22 nM. TAK-041 can be used to study negative symptoms of schizophrenia. | ||
| M10785 | Atogepant | CGRP Receptor |
| MK-8031; AGN-241689 | ||
| Atogepant (MK-8031) is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist. Atogepant can be used for the research of migraine. | ||
| M11306 | Etelcalcetide hydrochloride | Calcium-sensing Receptor |
| AMG 416 hydrochloride; KAI-4169 hydrochloride | ||
| Etelcalcetide Hydrochloride (AMG 416 Hydrochloride) is a synthetic peptide that acts as a calcium-sensitive receptor (CaSR) activator. Etelcalcetide hydrochloride effectively reduces parathyroid hormone (PTH) concentration in patients with secondary hyperparathyroidism undergoing hemodialysis. | ||
| M14426 | URB-597 | FAAH |
| KDS-4103 | ||
| URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. | ||
| M20793 | Amitriptyline | Serotonin Transporter |
| MK-230; N-750; Ro41575 | ||
| Amitriptyline (MK-230, N-750, Ro41575) is an inhibitor of the serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki values of 3.45 nM and 13.3 nM, respectively, and also inhibits the histamine receptor H1, the histamine receptor H4, 5-HT2, and the Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. It can also inhibit histamine receptor H1, histamine receptor H4, 5-HT2 and Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively, and can be used in studies of depression and neuropathic pain. | ||
| M21127 | TAK-418 | Histone demethylase |
| TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC50 of 2.9 nM. It is an orally administered CNS-permeable clinical candidate for the study of neurodevelopmental disorders, such as autism spectrum disorders. | ||
| M27673 | GSK2041706A | GPR/FFAR |
| GSK706 | ||
| GSK2041706A (GSK706) is a potent G protein-coupled receptor 119 (GPR119) agonist. GSK2041706A can be used for the research of type 2 diabetes. | ||
| M27712 | Uprosertib hydrochloride | Akt |
| GSK2141795 (hydrochloride) | ||
| Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. | ||
| M27751 | PK14105 | Others |
| PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors. in vivo binding experiments, in which PK 14105 was injected into rats with unilaterally lesioned striata, demonstrate that PK 14105 rapidly crosses the blood-brain-barrier and that there is a marked retention of radioactivity in the lesioned striatum not seen in the unlesioned striatum or cerebellar vermis. It can also inhibit receptor ligands, calcium channel ligands and co-transporter in all salivary glands. | ||
| M27831 | MK-0941 | Glucokinase (GK) |
| MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes. | ||
| M27901 | TAK-441 | Hedgehog |
| TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC50value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors. | ||
| M28089 | Etelcalcetide | Calcium-sensing Receptor |
| AMG 416; KAI-4169 | ||
| Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis. | ||
| M28796 | Rodatristat | 5-HT Receptor |
| KAR5417 | ||
| Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice. | ||
| M29240 | DK419 | Wnt/beta-catenin |
| DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK. | ||
| M29454 | ZK824190 | Serine/Threonine Protease |
| ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively. | ||
| M29739 | ZK824190 hydrochloride | Serine/Threonine Protease |
| ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively. | ||
| M30576 | MK-0941 free base | Glucokinase (GK) |
| MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes. | ||
| M30623 | MK-4541 | Androgen Receptor |
| MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model. | ||
| M40558 | GSK3745417 | STING |
| GSK3745417 is a STING1 agonist that can be used in tumor-related studies. | ||
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