About 22 results found for searched term "GABA-IN-2" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43180 | GABA-IN-2 | Others |
| GABA-IN-2 is a GABA inhibitor. | ||
| M6092 | Mirogabalin | Calcium Channel |
| DS5565 | ||
| Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS. | ||
| M21509 | Afizagabar | GABA Receptor |
| S44819; Egis-13529 | ||
| Afizagabar (S44819) is a first-in-class, competitive and selective α5-GABAAR antagonist with an IC50 value of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. | ||
| M27809 | Abecarnil | GABA Receptor |
| ZK 112119 | ||
| Abecarnil (ZK 112119) is a ligand or a partial agonist for benzodiazepine (BZ) receptor. Abecarnil possesses anxiolytic and anticonvulsant properties. Abecarnil can act as a positive allosteric modulator of GABAA receptor. Abecarnil inhibits the binding of the BZ [3H]lormetazepam to rat cerebral cortex membranes, with an IC50 of 0.82 nM. Abecarnil can be used for epilepsy research. | ||
| M27832 | Mirogabalin besylate | Calcium Channel |
| DS 5565 besylate | ||
| Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively. | ||
| M27881 | 2-Hydroxysaclofen | GABA Receptor |
| 2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABAB) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats. | ||
| M28621 | (S)-SNAP5114 | GABA Receptor |
| (S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant agent. | ||
| M28688 | PF-06372865 | GABA Receptor |
| Darigabat | ||
| PF-06372865 is an orally active, α2/α3/α5 subtype-selective GABAA positive allosteric modulator (PAM). PF-06372865 is a high affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. PF-06372865 can across the blood-brain barrier (BBB). PF-06372865 has anxiolytic activity and has the potential for epilepsy. | ||
| M29887 | BPDBA | GABA Receptor |
| BPDBA is a selective and noncompetitive betaine/GABA transporter (BGT-1) inhibitor with IC50s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively. | ||
| M30031 | Bicuculline methochloride | GABA Receptor |
| (+)-Bicuculline methochloride; d-Bicuculline methochloride | ||
| Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC50 value of 3 μM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca2+ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders. | ||
| M30053 | Bicuculline methiodide | GABA Receptor |
| (+)-Bicuculline methiodide; d-Bicuculline methiodide | ||
| Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current. | ||
| M30145 | Gabapentin enacarbil | Calcium Channel |
| XP-13512 | ||
| Gabapentin enacarbil (XP-13512) is a precursor for the anticonvulsant and analgesic drug gabapentin. | ||
| M30253 | (-)-Bicuculline methochloride | GABA Receptor |
| l-Bicuculline methochloride | ||
| (-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABAA receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons. | ||
| M30360 | β-Amino Acid Imagabalin Hydrochloride | Calcium Channel |
| PD-0332334 | ||
| β-Amino Acid Imagabalin Hydrochloride (PD-0332334) is a ligand for the α2δ subunit of the voltage-dependent calcium channel. | ||
| M30436 | Bicuculline methobromide | GABA Receptor |
| (+)-Bicuculline methobromide; d-Bicuculline methobromide | ||
| Bicuculline methobromide is a selective GABAA Receptor antagonist with an IC50 value of 3 μM. Bicuculline methobromide induces clonic tonic convulsions in mammals and can also be used to block Ca2+ activated potassium channels. Bicuculline methobromide can be used in studies of epilepsy and other related psychiatric disorders. | ||
| M30556 | (-)-Bicuculline methobromide | GABA Receptor |
| l-Bicuculline methobromide | ||
| (-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons. | ||
| M30609 | FG 7142 | GABA Receptor |
| ZK 39106; LSU-65 | ||
| FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. | ||
| M39028 | Picrotin | GABA Receptor |
| Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs/b> with IC50 values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission. | ||
| M40537 | Lotilaner | Parasite |
| Lotilaner is a first-in-class, highly selective inhibitor of gamma-aminobutyric acid (GABA) gated chloride channels (GABACls) against mites. It has antiparasitic activity with an IC50 value of 23.84 nM against the Drosophila GABA receptor and can be used in studies related to helminth mite blepharitis. | ||
| M42177 | SCS | GABA Receptor |
| SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. | ||
| M45171 | L-2,4-Diaminobutyric acid dihydrochloride | GABA Receptor |
| L-2,4-Diaminobutyric acid dihydrochloride inhibits GABA transaminase activity, resulting in elevated GABA levels, and exhibits ex vivo antitumor activity against mouse fibrosarcoma cells. In addition, L-2,4-Diaminobutyric acid dihydrochloride can be used as an internal standard for amino acid analysis. | ||
| M56488 | TPMPA | GABA Receptor |
| TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). | ||
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