Free shipping on all orders over $ 500

Bicuculline methochloride

Cat. No. M30031

All AbMole products are for research use only, cannot be used for human consumption.

Bicuculline methochloride Structure
Synonym:

(+)-Bicuculline methochloride; d-Bicuculline methochloride

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC50 value of 3 μM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca2+ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders.

Chemical Information
Molecular Weight 417.84
Formula C21H20ClNO6
CAS Number 38641-83-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Jinny J Yoon, et al. Int J Neurosci. Effect of low Mg2+ and bicuculline on cell survival in hippocampal slice cultures

[2] R W Olsen, et al. Eur J Pharmacol. Autoradiographic localization of low affinity GABA receptors with [3H]bicuculline methochloride

[3] R W Olsen, et al. J Neurochem. [3H]bicuculline methochloride binding to low-affinity gamma-aminobutyric acid receptor sites

[4] G A Johnston, et al. Nat New Biol. Bicuculline methochloride as a GABA antagonist

[5] A Dray. Neuropharmacology. Comparison of bicuculline methochloride with bicuculline and picrotoxin as antagonists of amino acid and monoamine depression of neurones in the rat brainstem

Related GABA Receptor Products
β-CCB 

β-CCB is a ligand for benzodiazepine receptor, which inhibits the binding of [3H]flunitrazepam and ethyl (3-[3H]carboline-3-carboxylate to benzodiazepine receptors, with Ki of 3-4 nM.
TPMPA 

TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM).
CI-966 

CI-966 is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter GAT-1, with IC50s of 0.26 μM and 1.2 μM for hGAT-1, rGAT-1, respectively.
NCS-382 

NCS-382 is a potent GABA receptor antagonist and also a GHBR receptor antagonist.
CGS 8216 

CGS 8216, a benzodiazepine receptor antagonist, inhibits 3H-flunitrazepam (3H-FLU) binding to rat synaptosomal membranes in vitro at subnanomolar concentrations.
  Catalog
Abmole Inhibitor Catalog




Keywords: Bicuculline methochloride, (+)-Bicuculline methochloride; d-Bicuculline methochloride supplier, GABA Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.