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Bicuculline methiodide

Cat. No. M30053

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Bicuculline methiodide Structure
Synonym:

(+)-Bicuculline methiodide; d-Bicuculline methiodide

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Quality Control & Documentation
Biological Activity

Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current.

Chemical Information
Molecular Weight 509.29
Formula C21H20INO6
CAS Number 40709-69-1
Solubility (25°C) DMSO 150 mg/mL (ultrasonic)
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Dur-Zong Hsu, et al. Shock. Bicuculline methiodide attenuates hepatic injury and decreases mortality in septic rats: role of cytokines

[2] P Mares, et al. Epilepsy Res. Convulsant action of systemically administered glutamate and bicuculline methiodide in immature rats

[3] S W Johnson, et al. Neurosci Lett. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents

[4] M P Remler, et al. Epilepsia. Bicuculline methiodide in the blood-brain barrier-epileptogen model of epilepsy

[5] A W Barolet, et al. Can J Physiol Pharmacol. Antagonist actions of bicuculline methiodide and picrotoxin on extrasynaptic gamma-aminobutyric acid receptors

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Keywords: Bicuculline methiodide, (+)-Bicuculline methiodide; d-Bicuculline methiodide supplier, GABA Receptor, inhibitors, activators

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