Free shipping on all orders over $ 500

2-Hydroxysaclofen 

Cat. No. M27881
2-Hydroxysaclofen  Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABAB) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats.

Chemical Information
Molecular Weight 265.71
Formula C9H12ClNO4S
CAS Number 117354-64-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Andrés P Varani, et al. Eur J Pharmacol. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine

[2] Florencio Miranda, et al. Pharmacol Biochem Behav. The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure

[3] Ken Kasamatsu, et al. Am J Physiol Regul Integr Comp Physiol. Depressor and bradycardic responses to microinjections of endomorphin-2 into the NTS are mediated via ionotropic glutamate receptors

[4] D I Kerr, et al. Eur J Pharmacol. The (S)-enantiomer of 2-hydroxysaclofen is the active GABAB receptor antagonist in central and peripheral preparations

[5] T Akema, et al. Brain Res. 2-Hydroxysaclofen, a potent GABAB receptor antagonist, stimulates luteinizing hormone secretion in female rats

Related GABA Receptor Products
Alogabat

Alogabat (RG-7816) is a GABAA α5 receptor positive allosteric modulators (PAMs).
CGP7930

CGP7930 (3-(3’,5’-Di-tert-butyl-4’-hydroxy) phenyl-2, 2-dimethylpropanol) is a positive metabotropic GABAB receptor allosteric modulator.
5-Aminovaleric acid

5-Aminovaleric acid is a GABA receptor antagonist.
L-2,4-Diaminobutyric acid dihydrochloride

L-2,4-Diaminobutyric acid dihydrochloride inhibits GABA transaminase activity, resulting in elevated GABA levels, and exhibits ex vivo antitumor activity against mouse fibrosarcoma cells. In addition, L-2,4-Diaminobutyric acid dihydrochloride can be used as an internal standard for amino acid analysis.
3,4,5-Trimethoxy-trans-cinnamic acid

(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups.
  Catalog
Abmole Inhibitor Catalog




Keywords: 2-Hydroxysaclofen  supplier, GABA Receptor, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.