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Lotilaner is a gamma-aminobutyric acid (GABA)-gated chloride channel inhibitor that is highly selective against mites. It has antiparasitic activity with an IC50 value of 23.84 nM against the Drosophila GABA receptor and can be used in studies related to helminth mite blepharitis.
| Molecular Weight | 596.76 |
| Formula | C20H14Cl3F6N3O3S |
| CAS Number | 1369852-71-0 |
| Form | Solid |
| Solubility (25°C) | DMSO >100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Yahiya Y Syed. Drugs. Lotilaner Ophthalmic Solution 0.25%: First Approval
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