Certificate of Analysis
| Product Name: | Lotilaner |
| Catalog Number: | M40537 |
| CAS Number: | 1369852-71-0 |
Physical and Chemical Properties
| Formula: | C20H14Cl3F6N3O3S |
| Molecular Weight: | 596.76 |
| Form: | Solid |
| Solubility: | DMSO >100 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Lotilaner is a first-in-class, highly selective inhibitor of gamma-aminobutyric acid (GABA) gated chloride channels (GABACls) against mites. It has antiparasitic activity with an IC50 value of 23.84 nM against the Drosophila GABA receptor and can be used in studies related to helminth mite blepharitis. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |