About 31 results found for searched term "ET receptor antagonist 3" (0.077 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43592 | ET receptor antagonist 3 | Estrogen Receptor |
| ET receptor antagonist 3 is an orally active ET receptor antagonist (IC50=0.26 nM), which can be used for research in pulmonary arterial hypertension (PAH). | ||
| M2646 | Dizocilpine | NMDA |
| MK-801 | ||
| Dizocilpine (MK-801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM. | ||
| M2717 | Galeterone | Androgen Receptor |
| TOK-001 | ||
| Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. | ||
| M3234 | (R)-Bicalutamide | Androgen Receptor |
| (R)-Bicalutamide is an active competitive non-steroidal androgen receptor antagonist with an IC50 of 0.17 μM for MDA 453 cells. | ||
| M3261 | Almorexant | OX Receptor |
| ACT-078573 | ||
| Almorexant is a competitive OX1 and OX2 orexin receptor antagonist with IC50 of 13 and 8 nM, respectively. | ||
| M3320 | Quetiapine Fumarate | 5-HT Receptor |
| Quetiapine hemifumarate | ||
| Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. | ||
| M3331 | Trospium chloride | AChR/AChE |
| Trospium chloride is an orally active, competitive muscarinic cholinergic receptors (mAChRs) antagonist. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors. | ||
| M3453 | Scopolamine hydrobromide | Animal Modeling |
| (-)-Scopolamine hydrobromide; Hyoscine hydrobromide; Scopine hydrobromide | ||
| Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.It can be used to construct animal models of dry eye. | ||
| M3460 | Colchicine | Microtubule |
| Colchicine is a natural product extracted from Colchicum spp. It is also a tubulin inhibitor and microtubule disruptor with an IC50 of 3 nM for inhibition of microtubule polymerization, and a competitive antagonist of α3 glycine receptors (GlyRs). Colchicine is also a competitive antagonist of α3 Glycine receptors (GlyRs) and has been used in gout research. | ||
| M1565 | Quetiapine sulfoxide | 5-HT Receptor |
| Quetiapine sulfoxide; Quetiapine S-oxide | ||
| Quetiapine sulfoxide is a 5-HT receptor agonist with a pEC50 value of 4.77 for human 5-HT1A. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 value of 6.33 for human D2. | ||
| M1564 | Quetiapine Sulfone | 5-HT Receptor |
| Quetiapine Sulfone is a 5-HT receptor agonist with a pEC50 value of 4.77 for human 5-HT1A. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 value of 6.33 for human D2. | ||
| M5942 | Roxatidine Acetate HCl | Histamine Receptor |
| HOE 760 | ||
| Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation. | ||
| M6416 | AGN 193109 | RAR/RXR |
| AGN193109 | ||
| AGN 193109 is a high affinity pan-RAR (retinoic acid receptors) antagonist, with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. | ||
| M6457 | AR-C 118925XX | P2 Receptor |
| ARC118925XX | ||
| AR-C 118925XX is a selective, competitive P2Y2 receptor antagonist. AR-C 118925XX is inactive against a panel of 37 other receptors at a concentration of 10 μM. AR-C 118925XX inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50 = 1 μM). AR-C 118925XX inhibits P2Y2 receptor-induced β-arrestin translocation in vitro (pA2 = 37.2-51.3 nM). | ||
| M6619 | CNQX | GluR |
| FG9065 | ||
| CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. | ||
| M6621 | Conantokin-R | Others |
| Con-R | ||
| Conantokin-R is a potent, non-competitive NMDA receptor peptide antagonist with an IC50 of 93 nM.Conantokin-R is also NR2 subunit selective. It inhibits the inward current induced by NMDA in CNS neurons (IC50 = 350 nM). In addition, Conantokin R bound to Zn2+ and Mg2+ with Kd of 0.15 μM and 6.5 μM, respectively. | ||
| M7327 | Lintitript | Cholecystokinin Receptor |
| SR 27897 | ||
| Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC50 value of 200 nM). | ||
| M7581 | Dizocilpine maleate | NMDA |
| Dizocilpine hydrogen maleate; (+)-MK 801 maleate; MK-801 maleate | ||
| Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes. | ||
| M8349 | AE9C90CB | Others |
| AE9C90CB is a muscarinic acetylcholine receptor antagonist with 20-fold selectivity for M3 receptor subtypes compared to M2. | ||
| M8700 | PCS1055 dihydrochloride | Others |
| PCS1055 is a potent and selective muscarinic M4 acetylcholine receptor competitive antagonist that exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. | ||
| M10332 | Vapreotide acetate | Neurokinin Receptor |
| BMY-41606; RC160; Octastatin acetate | ||
| Vapreotide acetate (BMY-41606 acetate; RC160 acetate) is a neurokinin-1 (NK1) receptor antagonist with IC50 value of 330 nM. | ||
| M10480 | Tetraiodothyroacetic acid (tetrac) | Integrin |
| 3,3',5,5'-Tetraiodothyroacetic acid; Tetrac | ||
| Tetraiodothyroacetic acid (tetrac) is a thyrointegrin receptor antagonist. Tetraiodothyroacetic acid blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. | ||
| M10654 | Ajmalicine (Raubasine) | Adrenergic Receptor |
| Raubasine | ||
| Ajmalicine (Raubasine) is an adrenolytic agent which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor. Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM. | ||
| M10916 | RO 46-8443 | Endothelin Receptor |
| RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. | ||
| M11344 | JMV 2959 | Ghrelin Receptor/GHSR |
| JMV 2959 is a growth hormone secretin receptor type 1A (GHS-R1A) antagonist that acts on LC-PK1 cells and inhibits GHS-R1A with an IC50 value of 32±3 nM. | ||
| M13375 | Cetrorelix Acetate | LHRH/GnRH |
| Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. Sequence：Ac-D2Nal-D4Cpa-D3Pal-Ser-Tyr-DCit-Leu-Arg-Pro-DAla-NH2 | ||
| M13876 | SB-269970 hydrochloride | 5-HT Receptor |
| SB-269970A | ||
| SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 hydrochloride exhibits >50-fold selectivity against other 5-HT receptors. | ||
| M13879 | Tropisetron | 5-HT Receptor |
| SDZ-ICS-930 free base | ||
| Tropisetron (SDZ-ICS-930 free base) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. | ||
| M13880 | Tropisetron Hydrochloride | 5-HT Receptor |
| SDZ-ICS-930 | ||
| Tropisetron Hydrochloride (SDZ-ICS-930) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. | ||
| M13899 | SR59230A hydrochloride | Adrenergic Receptor |
| SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively. | ||
| M13965 | JMV 2959 hydrochloride | Others |
| JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells. | ||
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