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Tetraiodothyroacetic acid (tetrac) is a thyrointegrin receptor antagonist. Tetraiodothyroacetic acid blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. 3,3',5,5'-Tetraiodothyroacetic acid has anti-angiogenic and anti-tumor activities.
| Molecular Weight | 747.83 |
| Formula | C14H8I4O4 |
| CAS Number | 67-30-1 |
| Solubility (25°C) | DMSO 50 mg/mL acetone 18 mg/mL |
| Storage | -20°C, protect from light, sealed |
[1] Paul J Davis, et al. Physiol Rev. Nongenomic Actions of Thyroid Hormone: The Integrin Component
[2] Kathrin A Schmohl, et al. Endocr Relat Cancer. Tetrac as an anti-angiogenic agent in cancer
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