About 11 results found for searched term "67-30-1" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10480 | Tetraiodothyroacetic acid (tetrac) | Integrin |
| 3,3',5,5'-Tetraiodothyroacetic acid; Tetrac | ||
| Tetraiodothyroacetic acid (tetrac) is a thyrointegrin receptor antagonist. Tetraiodothyroacetic acid blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. | ||
| M30454 | PG-931 | Melanocortin Receptor |
| PG-931, an analog of SHU 9119, is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo. | ||
| M30469 | Facinicline hydrochloride | AChR/AChE |
| RG3487 hydrochloride | ||
| Facinicline hydrochloride (RG3487 hydrochloride) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride (RG3487 hydrochloride) shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM. | ||
| M43111 | ZK 93426 hydrochloride | Others |
| ZK 93426 (hydrochloride) is a benzodiazepine antagonist. | ||
| M11245 | PF-06726304 | Histone Methyltransferase |
| PF-6726304 | ||
| Pf-06726304 is an effective selective EZH2 inhibitor. Pf-06726304 inhibited wild type and Y641N mutant EZH2 with Ki of 0.7 and 3.0 nM, respectively. Pf-06726304 has strong anti-tumor growth activity. | ||
| M14590 | MRT67307 | IκB/IKK |
| MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells. | ||
| M20515 | Emedastine | Histamine Receptor |
| Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM). | ||
| M21262 | FT3967385 | Deubiquitinase |
| FT385 | ||
| FT3967385 is a novel USP30 inhibitor that recapitulates the genetic deletion of USP30 and triggers mitochondrial ubiquitination of PINK1-PARKIN amplification. | ||
| M28820 | AZ-PFKFB3-67 | PFKFB3 |
| AZ-PFKFB3-67 is potent and selective metabolic kinase PFKFB3 inhibitor, with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively. | ||
| M31070 | AZ-PFKFB3-67 quarterhydrate | PFKFB3 |
| AZ-PFKFB3-67 quarterhydrate is potent and selective metabolic kinase PFKFB3 inhibitor, with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively. | ||
| M42726 | MRT67307 dihydrochloride | IκB/IKK |
| MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. | ||
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