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Facinicline hydrochloride (RG3487 hydrochloride) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride (RG3487 hydrochloride) shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM.
| Molecular Weight | 306.79 |
| Formula | C15H19ClN4O |
| CAS Number | 677305-02-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 125 mg/mL (ultrasonic) Water 100 mg/mL (ultrasonic) |
| Storage | 4°C, dry, sealed |
[3] Chuangchuang Xu, et al. Org Biomol Chem. Metal-free and regiospecific synthesis of 3-arylindoles
[4] No authors listed. Carteolol
[5] S Groszkowski, et al. Pol J Pharmacol Pharm. 1-Haloacylpiperazines
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