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SR 59230A

Cat. No. M8197

All AbMole products are for research use only, cannot be used for human consumption.

SR 59230A Structure
Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 240  USD240 In stock
50mg USD 850  USD850 In stock
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Quality Control & Documentation
Biological Activity

SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.1 It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.2

Chemical Information
Molecular Weight 415.48
Formula C21H27NO2 · C2H2O4
CAS Number 174689-39-5
Form Solid
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jia-Ni Jing, et al. SR 59230A on the expression of MicroRNAs in myocardium of heart failure rats

[2] U S Pettersson, et al. Reversal of high pancreatic islet and white adipose tissue blood flow in type 2 diabetic GK rats by administration of the beta3-adrenoceptor inhibitor SR-59230A

[3] A MacDonald, et al. Characterisation of the atypical beta-adrenoceptor in rabbit isolated jejunum using BRL 37344, cyanopindolol and SR 59230A

[4] M Dumas, et al. Influence of beta-adrenoceptor agonists on the pulmonary circulation. Effects of a beta3-adrenoceptor antagonist, SR 59230A

[5] E Nisoli, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes

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Keywords: SR 59230A supplier, Adrenergic Receptor, inhibitors, activators

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