About 30 results found for searched term "EN4" (0.006 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1708 | Selisistat | Sirtuin |
| EX 527; SEN0014196 | ||
| Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. | ||
| M1761 | Vemurafenib (PLX4032) | Raf |
| RG7204; RO5185426 | ||
| Vemurafenib (PLX4032) is a first-in-class, potent, selective inhibitor of B-Raf that inhibits RAFV600E and C-RAF-1 activity with IC50s of 31 nM and 48 nM, respectively.In addition, Vemurafenib induces autophagy. | ||
| M1971 | Maraviroc | CCR |
| Selzentry, Celsentri, UK-427857 | ||
| Maraviroc (UK-427857) is a selective CCR5 antagonist with potent anti-human immunodeficiency virus type 1 (HIV-1) activity and favorable pharmacological properties. | ||
| M2234 | Prasugrel | P2 Receptor |
| Effient, Efient; PCR 4099 | ||
| Prasugrel is a platelet inhibitor irreversibly binding to P2Y12 receptors. | ||
| M2278 | Bosentan Hydrate | Endothelin Receptor |
| Benzenesulfonamide Hydrate; Ro-47-0203 Hydrate | ||
| Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M2280 | Tamoxifen Citrate (ICI 46474) | Estrogen Receptor |
| ICI 46474; Istubal; Nolvadex | ||
| Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding. | ||
| M2381 | AMD3465 hexahydrobromide (AMD3465 ) | CXCR |
| GENZ-644494 hexahydrobromide | ||
| AMD3465 hexahydrobromide（AMD3465 ) is an effective CXCR4 antagonist that inhibits 12G5 mAb in SupT1 cells. The IC50 values of CXCL12AF647 and CXCR4 were 0.75 nM and 18 nM, respectively. AMD 3465 also effectively inhibited X4 HIV replication (IC50, 1-10 nM), but not R5 HIV replication. | ||
| M2454 | Betamipron | Antibiotic |
| N-Benzoyl-β-alanine; CS-443 | ||
| Betamipron is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity. | ||
| M2467 | Bosentan | Endothelin Receptor |
| Benzenesulfonamide; Ro-47-0203 | ||
| Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M2719 | G-418 disulfate | Antibiotic |
| Geneticin sulfate; G418 sulfate | ||
| G-418 disulfate (Geneticin) blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. | ||
| M3022 | Sodium Phenylbutyrate | HDAC |
| 4-PBA sodium; 4-Phenylbutyric acid sodium; Sodium 4-phenylbutyrate; TriButyrate | ||
| Sodium Phenylbutyrate (4-PBA sodium) is a transcriptional regulators that act by altering chromatin structure via the modulation of HDAC activity. | ||
| M3026 | Sorafenib (BAY 43-9006) | Raf |
| BAY 43-9006 | ||
| Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Sorafenib is a multikinase inhibitor with IC50 values of 15 nM, 20 nM, 57 nM and 58 nM for VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib is a ferroptosis activator. | ||
| M3155 | XEN445 | 5-HT Receptor |
| XEN445 is a potent and selective EL inhibitor (IC50=0.237 uM) which shows good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. | ||
| M3173 | Potassium canrenoate | Mineralocorticoid Receptor |
| Aldadiene potassium, SC-14266 | ||
| Canrenoate potassium is a predrug for the release of Canrenone and an effective antagonist of competitive salt ocorticoid receptor. As a diuretic, Canrenoate potassium is used in the study of hypertension. | ||
| M3201 | Azasetron dihydrochloride | 5-HT Receptor |
| Y-25130 2HCl; SENS-401 dihydrochloride | ||
| Azasetron dihydrochloride is the hydrochloride form of Azasetron and is also an orally active 5-HT3 receptor antagonist for studies related to ear disorders such as sudden hearing loss. | ||
| M3272 | Alendronate sodium hydrate | Others |
| Alendronate; MK 217; G-704650 Adronat | ||
| Alendronate is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. | ||
| M3301 | Acetaminophen | Animal Modeling |
| APAP; Paracetamol; Tylenol; 4-Acetamidophenol | ||
| Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M3416 | Mycophenolic acid | Immunology/Inflammation |
| Mycophenolate, RS-61443; MPA | ||
| Mycophenolic acid is an immunosuppressant agent used to prevent rejection in organ transplantation. | ||
| M3784 | Genz-644282 | Topoisomerase |
| Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay. | ||
| M3905 | Anemoside B4 | Others |
| Chinensioside A, Pulchinenoside C, Pulchinenoside B4 | ||
| Pulchinenoside C (Anemoside B4) is a natural Pulchinenoside B4, which has many biological effects, such as anti-tumor, neuroprotective, anti-angiogenic and other activities. | ||
| M3925 | Arctiin | Others |
| Arctii; NSC 315527; Arctigenin-4-glucoside | ||
| Arctiin is an active lignin isolated from Arctium lappa and has anti-inflammation, anti-microbial, and anti-carcinogenic effects. | ||
| M1580 | 4-Hydroxy phenyl carvedilol | Metabolite/Endogenous Metabolite |
| 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol | ||
| 4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol, which is a nonselective beta blocker/alpha-1 blocker. | ||
| M4086 | Ginsenoside-F4 | Apoptosis |
| Ginsenoside F4 (GF4), Ginsenoside, isolated from Panax notoginseng or red ginseng. Ginsenoside F4 (GF4) can inhibit human lymphocytic tumor JK cells by inducing apoptosis. Ginsenoside F4 (GF4) inhibited the expression of matrix metalloproteinase 13 (MMP 13) in IL-1β -treated chondrocytes, blocked cartilage damage in rabbit cartilage tissue culture, and prevented cartilage collagen matrix decomposition in pathological tissues. | ||
| M4133 | Saponin-V | Others |
| Presapogenin-CP4 | ||
| Saponin-V | ||
| M4540 | Scutellarein | Src-bcr-Abl |
| 6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone | ||
| Scutellarein is a natural flavonoid with anti-inflammatory effects. | ||
| M4623 | 3β-acetoxy-eupha-7-25-dien-24(R)-ol | Others |
| 3β-acetoxy-eupha-7-25-dien-24(R)-ol | ||
| M4628 | Presapogenin-CP4 | Others |
| Presapogenin CP4 extracted from Anemone hupehensis. | ||
| M4812 | Genz-123346 | Others |
| Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1. | ||
| M4991 | Dihydroartemisinin | Parasite |
| β-Dihydroartemisinin; DHA; Artenimol; CAS# 81496-82-4 | ||
| Dihydroartemisinin is a potent anti-malaria agent. Dihydroartemisinin, a derivative of artemisinin in which the C-10 lactone group is replaced by hemiacetals and active metabolites of all artemisinin compounds, is a widely used antimalarial compound that effectively induces iron death in acute myeloid leukemia cells (HL60, KG1, and THP-1) by regulating iron metabolism. | ||
| M5359 | 2,2′-Dihydroxy-4-methoxybenzophenone | Others |
| Benzophenone-8; UV-24 | ||
| Dioxybenzone is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. | ||
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