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Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cells, such as osteosarcoma, lung, colorectal, cervical, breast, melanoma, and prostate cancer. Arctiin has shown antiviral activity against influenza A when used along or in combination with oseltamivir. It was recently reported that arctiin induces growth inhibition in human prostate cancer PC-3 cells. Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the down-regulation of cyclin D1 protein expression. Arctiin has a protective effect on ROS-induced cell dysfunction in HHDPCs and may therefore be useful for alopecia prevention and treatment strategies.
| Molecular Weight | 534.55 |
| Formula | C27H34O11 |
| CAS Number | 20362-31-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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