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Acetaminophen

Cat. No. M3301
Acetaminophen Structure
Synonym:

APAP; Paracetamol; Tylenol; 4-Acetamidophenol

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 40  USD40 In stock
1g USD 45  USD45 In stock
5g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Acetaminophen is a highly selective inhibitor of COX-2 and 6-keto-PGF1 alpha with IC50 of 302.3 mg/kg and 10 uM, respectively. Administration of high-dose AAP [302.3 mg/kg (IC50 for COX-2)] or PHE [179.2 mg/kg (IC50 for COX-2)] and of non-specific (indomethacin: 20 mg/kg) or specific COX-2 (NS-398: 10 mg/kg) inhibitor impaired the performance in hidden platform (HP) not visible platform (VP) tasks, whereas low-dose (15.1 mg/kg) AAP facilitated performance in HP and VP tasks. Nanomolar concentrations of peroxynitrite increased the activity of isolated PGHS and prostacyclin formation by aortic endothelial cells. This elevated activity was efficiently inhibited by pharmacologically relevant concentrations of acetaminophen (IC50 approximately 10 uM for 6-keto-PGF1alpha) and other free radical scavengers.

*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information
Molecular Weight 151.16
Formula C8H9NO2
CAS Number 103-90-2
Solubility (25°C) DMSO 20 mg/mL
Water 8 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Clyde J Wright. Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?

[2] Kelly L Hayward, et al. Can paracetamol (acetaminophen) be administered to patients with liver impairment?

[3] Anita Aminoshariae, et al. Acetaminophen: old drug, new issues

[4] K Brune, et al. Acetaminophen/paracetamol: A history of errors, failures and false decisions

[5] Marta Jźwiak-Bebenista, et al. Paracetamol: mechanism of action, applications and safety concern

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Keywords: Acetaminophen, APAP; Paracetamol; Tylenol; 4-Acetamidophenol supplier, Animal Modeling, inhibitors, activators


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