About 9 results found for searched term "Acetaminophen" (0.138 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3301 | Acetaminophen | Animal Modeling |
| APAP; Paracetamol; Tylenol; 4-Acetamidophenol | ||
| Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M1590 | 3-HYDROXYACETAMINOPHEN | Metabolite/Endogenous Metabolite |
| 3-Hydroxyacetaminophen | ||
| 3-hydroxy-acetaminophen is a metabolite of Acetaminophen, which is a pain medicine. | ||
| M38974 | Acetaminophen-d3 | COX |
| Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. | ||
| M4012 | Licochalcone-A | Autophagy |
| Licochalcone-A; Lico A | ||
| Licochalcone A is an estrogenic flavonoid derived from licorice that induces Nrf2-mediated defense mechanisms and ameliorates acetaminophen and endotoxin-induced liver injury. In addition, Licochalcone A has antimalarial, anticancer, antibacterial and antiviral activities. | ||
| M10919 | Mito-TEMPO | Mitochondrial Related |
| MitoTEMPO | ||
| Mito-TEMPO (MT) is a mitochondrial-targeted superoxide dismutase mimetic that protects the early stages of acetaminophen (APAP) hepatotoxicity by inhibiting the formation of peroxynitrite. Mito-TEMPO treatment inhibits APAP-induced EXPRESSION OF RIP3 kinase. | ||
| M27810 | NecroX-7 | HMGB1 |
| NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research. | ||
| M29429 | DI-1859 | E1/E2/E3 Enzyme |
| DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage. | ||
| M30204 | NAPQI | Metabolite/Endogenous Metabolite |
| NAPQI is the toxic metabolite of Acetaminophen. NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver. | ||
| M52542 | Ac-Leu-Leu-Norleucinol | Proteasome |
| Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST). | ||
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